Pilot study of the effect of postoperative imiquimod 5% cream on the recurrence rate of excised keloids

Brian Berman, Joely Kaufman

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

New adjunctive treatments are needed to reduce the high recurrence rates (50%) of excised keloids. Interferon alfa injections have been shown to decrease the size of stable keloids. This study examined the effects of postoperative imiquimod 5% cream on the recurrence of 13 keloids excised surgically from 12 patients. Starting on the night of surgery, imiquimod 5% cream was applied for 8 weeks. Patients were examined at weeks 4, 8, 16, and 24 for local erythema, edema, erosions, pigment alteration, and/or recurrence of keloids. Of the 11 keloids evaluated at 24 weeks, none (0%) recurred. Incidences of hyperpigmentation were 63.6%. Two cases of mild irritation and superficial erosion cleared with temporary discontinuation of imiquimod. Both patients completed the 8 weeks of topical therapy and the final 24-week assessment. At 24 weeks, the recurrence rate of excised keloids treated with postoperative imiquimod 5% cream was lower than recurrence rates previously reported in the literature.

Original languageEnglish (US)
JournalJournal of the American Academy of Dermatology
Volume47
Issue number4 SUPPL.
DOIs
StatePublished - Oct 1 2002

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imiquimod
Keloid
Recurrence
Hyperpigmentation
Erythema
Interferon-alpha
Edema
Injections

ASJC Scopus subject areas

  • Dermatology

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Pilot study of the effect of postoperative imiquimod 5% cream on the recurrence rate of excised keloids. / Berman, Brian; Kaufman, Joely.

In: Journal of the American Academy of Dermatology, Vol. 47, No. 4 SUPPL., 01.10.2002.

Research output: Contribution to journalArticle

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abstract = "New adjunctive treatments are needed to reduce the high recurrence rates (50{\%}) of excised keloids. Interferon alfa injections have been shown to decrease the size of stable keloids. This study examined the effects of postoperative imiquimod 5{\%} cream on the recurrence of 13 keloids excised surgically from 12 patients. Starting on the night of surgery, imiquimod 5{\%} cream was applied for 8 weeks. Patients were examined at weeks 4, 8, 16, and 24 for local erythema, edema, erosions, pigment alteration, and/or recurrence of keloids. Of the 11 keloids evaluated at 24 weeks, none (0{\%}) recurred. Incidences of hyperpigmentation were 63.6{\%}. Two cases of mild irritation and superficial erosion cleared with temporary discontinuation of imiquimod. Both patients completed the 8 weeks of topical therapy and the final 24-week assessment. At 24 weeks, the recurrence rate of excised keloids treated with postoperative imiquimod 5{\%} cream was lower than recurrence rates previously reported in the literature.",
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