Pilot study of intrahepatic artery chemotherapy in combination with sorafenib in hepatocellular carcinoma

Vy Dinh, Shivank Bhatia, Govindarajan Narayanan, Jose Yrizarry, Niramol Savaraj, Christopher B O'Brien, Paul Martin, Lynn G Feun

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background/Aim: Sorafenib and chemoembolization of the liver (TACE) have both produced increased survival in hepatocellular carcinoma (HCC). Some patients cannot tolerate TACE due to portal vein thrombosis or risk of liver failure. In this pilot trial, we aimed to combine intrahepatic infusion (IA) of cisplatin or carboplatin with sorafenib for unresectable HCC. Patients and Methods: Patients with Child's A or early B received IA cisplatin or carboplatin every 6 weeks with oral sorafenib. MRI/CT scans were performed every 6 weeks. Results: Eleven patients were accrued. Of 10 evaluable patients, 6 had clinical benefit (4 partial responses for 2+, 3+, 8+ and 18 months, 2 minor responses). Two patients were down-staged enough for ablation therapy or liver transplant and remain free of disease for 32+ and 36+ months. Toxicity was generally tolerable. Conclusion: Preliminary results are encouraging and this combination may down-stage some patients with unresectable disease.

Original languageEnglish (US)
Pages (from-to)3555-3563
Number of pages9
JournalAnticancer Research
Volume36
Issue number7
StatePublished - 2016

Keywords

  • Hepatocellular cancer
  • Intrahepatic chemotherapy
  • Sorafenib

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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