Pigmentary traits, modalities of sun reaction, history of sunburns, and melanocytic nevi as risk factors for cutaneous malignant melanoma in the italian population: Results of a collaborative case-control study

Luigi Naldi, G. Lorenzo Imberti, Fabio Parazzini, Silvano Gallus, Carlo La Vecchia, Tullio Cainelli, Alfredo Rebora, Gianni Tognoni, Andrea Peserico, F. Arcangeli, D. Calista, G. Landi, A. Di Landro, P. Puiatti, C. Catricalà, L. Eibenschutz, Roma S. Gallicano, G. Lo Scocco, V. Di Lernia, Antonella TostiC. Misciali, F. Scardigli, M. Cristofolini, M. Simonacci, M. Sigona, G. Pasolini, A. Manganoni, A. Lonati, R. Betti, A. Barba, F. De Agostini, C. Chieregato, G. Fabbrocini, N. Balato, P. Santoianni, M. G. Bertazzoni, P. Danese, I. Stanganelli, S. Moretti, Y. P. Carli, M. Iannantuono, P. Taddeucci, A. Virgili, G. Fenizi, E. Rossi, M. Pini, G. Galbiati, A. Locatelli

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

BACKGROUND. To the authors' knowledge, limited data are available from Mediterranean populations concerning risk factors for malignant melanoma. A few Italian case-control studies have produced conflicting results regarding the association between malignant melanoma and pigmentary traits, sunburns, and melanocytic nevi. METHODS. A case-control study was conducted within the framework of the Italian Group for Epidemiologic Research in Dermatology (GISED). Twenty-seven centers in the north and south of Italy participated. A total of 542 cases and 538 controls were entered onto the study. A standardized questionnaire was administered to cases and controls. Cases and controls also were examined by trained dermatologists who were required to count the number of melanocytic nevi (those measuring ≥ 2 mm and > 6 mm in greatest dimension, separately) and to make judgments regarding pigmentary traits. RESULTS. In the multivariate analysis, eye and skin color, propensity to sunburn, history of sunburns before age 15 years, and solar lentigines all were associated with malignant melanoma. In addition, the risk of melanoma increased with the number of melanocytic nevi ≥ 2 mm. Nevi > 6 mm in greatest dimension had effects on risk that appeared to be independent from the effects of smaller nevi (2-6 mm). CONCLUSIONS. The results of the current study largely are similar to those obtained in northern European countries, the U.S., and Australia and provide further evidence of the importance of selected pigmentary traits, sun exposure, and the number of melanocytic nevi in the risk of cutaneous malignant melanoma. (C) 2000 American Cancer Society.

Original languageEnglish
Pages (from-to)2703-2710
Number of pages8
JournalCancer
Volume88
Issue number12
DOIs
StatePublished - Jun 15 2000
Externally publishedYes

Fingerprint

Sunburn
Pigmented Nevus
Solar System
Case-Control Studies
Melanoma
Nevus
Population
Eye Color
Lentigo
Skin Pigmentation
Dermatology
Italy
Multivariate Analysis
Cutaneous Malignant Melanoma
Research

Keywords

  • Case-control study
  • Cutaneous malignant melanoma
  • Mediterranean populations
  • Melanocytic nevi
  • Pigmentary traits
  • Risk factors
  • Sunburns

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pigmentary traits, modalities of sun reaction, history of sunburns, and melanocytic nevi as risk factors for cutaneous malignant melanoma in the italian population : Results of a collaborative case-control study. / Naldi, Luigi; Imberti, G. Lorenzo; Parazzini, Fabio; Gallus, Silvano; La Vecchia, Carlo; Cainelli, Tullio; Rebora, Alfredo; Tognoni, Gianni; Peserico, Andrea; Arcangeli, F.; Calista, D.; Landi, G.; Di Landro, A.; Puiatti, P.; Catricalà, C.; Eibenschutz, L.; Gallicano, Roma S.; Lo Scocco, G.; Di Lernia, V.; Tosti, Antonella; Misciali, C.; Scardigli, F.; Cristofolini, M.; Simonacci, M.; Sigona, M.; Pasolini, G.; Manganoni, A.; Lonati, A.; Betti, R.; Barba, A.; De Agostini, F.; Chieregato, C.; Fabbrocini, G.; Balato, N.; Santoianni, P.; Bertazzoni, M. G.; Danese, P.; Stanganelli, I.; Moretti, S.; Carli, Y. P.; Iannantuono, M.; Taddeucci, P.; Virgili, A.; Fenizi, G.; Rossi, E.; Pini, M.; Galbiati, G.; Locatelli, A.

In: Cancer, Vol. 88, No. 12, 15.06.2000, p. 2703-2710.

Research output: Contribution to journalArticle

Naldi, L, Imberti, GL, Parazzini, F, Gallus, S, La Vecchia, C, Cainelli, T, Rebora, A, Tognoni, G, Peserico, A, Arcangeli, F, Calista, D, Landi, G, Di Landro, A, Puiatti, P, Catricalà, C, Eibenschutz, L, Gallicano, RS, Lo Scocco, G, Di Lernia, V, Tosti, A, Misciali, C, Scardigli, F, Cristofolini, M, Simonacci, M, Sigona, M, Pasolini, G, Manganoni, A, Lonati, A, Betti, R, Barba, A, De Agostini, F, Chieregato, C, Fabbrocini, G, Balato, N, Santoianni, P, Bertazzoni, MG, Danese, P, Stanganelli, I, Moretti, S, Carli, YP, Iannantuono, M, Taddeucci, P, Virgili, A, Fenizi, G, Rossi, E, Pini, M, Galbiati, G & Locatelli, A 2000, 'Pigmentary traits, modalities of sun reaction, history of sunburns, and melanocytic nevi as risk factors for cutaneous malignant melanoma in the italian population: Results of a collaborative case-control study', Cancer, vol. 88, no. 12, pp. 2703-2710. https://doi.org/10.1002/1097-0142(20000615)88:12<2703::AID-CNCR8>3.0.CO;2-Q
Naldi, Luigi ; Imberti, G. Lorenzo ; Parazzini, Fabio ; Gallus, Silvano ; La Vecchia, Carlo ; Cainelli, Tullio ; Rebora, Alfredo ; Tognoni, Gianni ; Peserico, Andrea ; Arcangeli, F. ; Calista, D. ; Landi, G. ; Di Landro, A. ; Puiatti, P. ; Catricalà, C. ; Eibenschutz, L. ; Gallicano, Roma S. ; Lo Scocco, G. ; Di Lernia, V. ; Tosti, Antonella ; Misciali, C. ; Scardigli, F. ; Cristofolini, M. ; Simonacci, M. ; Sigona, M. ; Pasolini, G. ; Manganoni, A. ; Lonati, A. ; Betti, R. ; Barba, A. ; De Agostini, F. ; Chieregato, C. ; Fabbrocini, G. ; Balato, N. ; Santoianni, P. ; Bertazzoni, M. G. ; Danese, P. ; Stanganelli, I. ; Moretti, S. ; Carli, Y. P. ; Iannantuono, M. ; Taddeucci, P. ; Virgili, A. ; Fenizi, G. ; Rossi, E. ; Pini, M. ; Galbiati, G. ; Locatelli, A. / Pigmentary traits, modalities of sun reaction, history of sunburns, and melanocytic nevi as risk factors for cutaneous malignant melanoma in the italian population : Results of a collaborative case-control study. In: Cancer. 2000 ; Vol. 88, No. 12. pp. 2703-2710.
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abstract = "BACKGROUND. To the authors' knowledge, limited data are available from Mediterranean populations concerning risk factors for malignant melanoma. A few Italian case-control studies have produced conflicting results regarding the association between malignant melanoma and pigmentary traits, sunburns, and melanocytic nevi. METHODS. A case-control study was conducted within the framework of the Italian Group for Epidemiologic Research in Dermatology (GISED). Twenty-seven centers in the north and south of Italy participated. A total of 542 cases and 538 controls were entered onto the study. A standardized questionnaire was administered to cases and controls. Cases and controls also were examined by trained dermatologists who were required to count the number of melanocytic nevi (those measuring ≥ 2 mm and > 6 mm in greatest dimension, separately) and to make judgments regarding pigmentary traits. RESULTS. In the multivariate analysis, eye and skin color, propensity to sunburn, history of sunburns before age 15 years, and solar lentigines all were associated with malignant melanoma. In addition, the risk of melanoma increased with the number of melanocytic nevi ≥ 2 mm. Nevi > 6 mm in greatest dimension had effects on risk that appeared to be independent from the effects of smaller nevi (2-6 mm). CONCLUSIONS. The results of the current study largely are similar to those obtained in northern European countries, the U.S., and Australia and provide further evidence of the importance of selected pigmentary traits, sun exposure, and the number of melanocytic nevi in the risk of cutaneous malignant melanoma. (C) 2000 American Cancer Society.",
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TY - JOUR

T1 - Pigmentary traits, modalities of sun reaction, history of sunburns, and melanocytic nevi as risk factors for cutaneous malignant melanoma in the italian population

T2 - Results of a collaborative case-control study

AU - Naldi, Luigi

AU - Imberti, G. Lorenzo

AU - Parazzini, Fabio

AU - Gallus, Silvano

AU - La Vecchia, Carlo

AU - Cainelli, Tullio

AU - Rebora, Alfredo

AU - Tognoni, Gianni

AU - Peserico, Andrea

AU - Arcangeli, F.

AU - Calista, D.

AU - Landi, G.

AU - Di Landro, A.

AU - Puiatti, P.

AU - Catricalà, C.

AU - Eibenschutz, L.

AU - Gallicano, Roma S.

AU - Lo Scocco, G.

AU - Di Lernia, V.

AU - Tosti, Antonella

AU - Misciali, C.

AU - Scardigli, F.

AU - Cristofolini, M.

AU - Simonacci, M.

AU - Sigona, M.

AU - Pasolini, G.

AU - Manganoni, A.

AU - Lonati, A.

AU - Betti, R.

AU - Barba, A.

AU - De Agostini, F.

AU - Chieregato, C.

AU - Fabbrocini, G.

AU - Balato, N.

AU - Santoianni, P.

AU - Bertazzoni, M. G.

AU - Danese, P.

AU - Stanganelli, I.

AU - Moretti, S.

AU - Carli, Y. P.

AU - Iannantuono, M.

AU - Taddeucci, P.

AU - Virgili, A.

AU - Fenizi, G.

AU - Rossi, E.

AU - Pini, M.

AU - Galbiati, G.

AU - Locatelli, A.

PY - 2000/6/15

Y1 - 2000/6/15

N2 - BACKGROUND. To the authors' knowledge, limited data are available from Mediterranean populations concerning risk factors for malignant melanoma. A few Italian case-control studies have produced conflicting results regarding the association between malignant melanoma and pigmentary traits, sunburns, and melanocytic nevi. METHODS. A case-control study was conducted within the framework of the Italian Group for Epidemiologic Research in Dermatology (GISED). Twenty-seven centers in the north and south of Italy participated. A total of 542 cases and 538 controls were entered onto the study. A standardized questionnaire was administered to cases and controls. Cases and controls also were examined by trained dermatologists who were required to count the number of melanocytic nevi (those measuring ≥ 2 mm and > 6 mm in greatest dimension, separately) and to make judgments regarding pigmentary traits. RESULTS. In the multivariate analysis, eye and skin color, propensity to sunburn, history of sunburns before age 15 years, and solar lentigines all were associated with malignant melanoma. In addition, the risk of melanoma increased with the number of melanocytic nevi ≥ 2 mm. Nevi > 6 mm in greatest dimension had effects on risk that appeared to be independent from the effects of smaller nevi (2-6 mm). CONCLUSIONS. The results of the current study largely are similar to those obtained in northern European countries, the U.S., and Australia and provide further evidence of the importance of selected pigmentary traits, sun exposure, and the number of melanocytic nevi in the risk of cutaneous malignant melanoma. (C) 2000 American Cancer Society.

AB - BACKGROUND. To the authors' knowledge, limited data are available from Mediterranean populations concerning risk factors for malignant melanoma. A few Italian case-control studies have produced conflicting results regarding the association between malignant melanoma and pigmentary traits, sunburns, and melanocytic nevi. METHODS. A case-control study was conducted within the framework of the Italian Group for Epidemiologic Research in Dermatology (GISED). Twenty-seven centers in the north and south of Italy participated. A total of 542 cases and 538 controls were entered onto the study. A standardized questionnaire was administered to cases and controls. Cases and controls also were examined by trained dermatologists who were required to count the number of melanocytic nevi (those measuring ≥ 2 mm and > 6 mm in greatest dimension, separately) and to make judgments regarding pigmentary traits. RESULTS. In the multivariate analysis, eye and skin color, propensity to sunburn, history of sunburns before age 15 years, and solar lentigines all were associated with malignant melanoma. In addition, the risk of melanoma increased with the number of melanocytic nevi ≥ 2 mm. Nevi > 6 mm in greatest dimension had effects on risk that appeared to be independent from the effects of smaller nevi (2-6 mm). CONCLUSIONS. The results of the current study largely are similar to those obtained in northern European countries, the U.S., and Australia and provide further evidence of the importance of selected pigmentary traits, sun exposure, and the number of melanocytic nevi in the risk of cutaneous malignant melanoma. (C) 2000 American Cancer Society.

KW - Case-control study

KW - Cutaneous malignant melanoma

KW - Mediterranean populations

KW - Melanocytic nevi

KW - Pigmentary traits

KW - Risk factors

KW - Sunburns

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