Phytoestrogens and bone health

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Purpose Of Review: The present review summarizes the results of epidemiological studies and clinical trials assessing the skeletal effects of soy foods and soy dietary supplements. Recent Findings: Results from epidemiological studies suggest a beneficial skeletal effect in Asian women consuming typical Asian diets, but clinical trials are conflictive regarding the effects of phytoestrogens on bone mineral density and bone turnover markers in premenopausal and postmenopausal women. Much of the controversy lies in differences in study design, reporting of results, participants' age and menopausal status, and type and dose of phytoestrogen used. Summary: Although western women will likely continue to incorporate soy foods and soy supplements into their diets with the increased availability of these products, published data are inconsistent and do not support soy's protective effect against bone loss. This conflicting evidence should be taken into account when considering using isoflavones in the prevention of bone loss and consequently fractures.

Original languageEnglish (US)
Pages (from-to)546-553
Number of pages8
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Issue number6
StatePublished - Dec 2010


  • bone
  • menopause
  • osteoporosis
  • phytoestrogens
  • soy isoflavones

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics


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