Abstract
Purpose: This prospective, randomized, double-blind study was performed to determine the effect of administration of physostigmine on the dose of propofol required to produce loss of consciousness. Methods: Forty female unpremedicated patients were assigned in a random blind design to receive either 2 mg physostigmine or equal volume of normal saline iv, five minutes before induction of anaesthesia with propofol. All patients received general anaesthesia for breast surgery. Propofol was infused at a constant rate of 200 ml · hr-1 while patients were breathing oxygen 100% via a face mask. In each patient the dose of propofol required to produce loss of the ability to grasp a 20 ml synnge was recorded as the end-point of loss of consciousness. At this point the protocol was terminated and, after intubation of the trachea, anaesthesia was maintained with a nitrous oxide-isoflurane or sevoflurane mixture in oxygen, increments of an opioid and a muscle relaxant. Doses of anaesthetic drugs and duration of anaesthesia vaned and depended on the type of breast surgery, determined by frozen section. Results: The mean ± SD dose of propofol required to produce loss of consciousness was 2.4 ± 0.6 mg · kg-1 and 2.0 ± 0.4 mg · kg-1 in the physostigmine and in the normal saline groups respectively (P = 0.014). Conclusion: Physostigmine pretreatment increases the dose of propofol required to produce loss of consciousness.
| Original language | English |
|---|---|
| Pages (from-to) | 1148-1151 |
| Number of pages | 4 |
| Journal | Canadian Journal of Anaesthesia |
| Volume | 44 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Physostigmine increases the dose of propofol required to induce anaesthesia. / Fassoulaki, Argyro; Sarantopoulos, Konstantinos D.; Derveniotis, Ch.
In: Canadian Journal of Anaesthesia, Vol. 44, No. 11, 01.11.1997, p. 1148-1151.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Physostigmine increases the dose of propofol required to induce anaesthesia
AU - Fassoulaki, Argyro
AU - Sarantopoulos, Konstantinos D.
AU - Derveniotis, Ch
PY - 1997/11/1
Y1 - 1997/11/1
N2 - Purpose: This prospective, randomized, double-blind study was performed to determine the effect of administration of physostigmine on the dose of propofol required to produce loss of consciousness. Methods: Forty female unpremedicated patients were assigned in a random blind design to receive either 2 mg physostigmine or equal volume of normal saline iv, five minutes before induction of anaesthesia with propofol. All patients received general anaesthesia for breast surgery. Propofol was infused at a constant rate of 200 ml · hr-1 while patients were breathing oxygen 100% via a face mask. In each patient the dose of propofol required to produce loss of the ability to grasp a 20 ml synnge was recorded as the end-point of loss of consciousness. At this point the protocol was terminated and, after intubation of the trachea, anaesthesia was maintained with a nitrous oxide-isoflurane or sevoflurane mixture in oxygen, increments of an opioid and a muscle relaxant. Doses of anaesthetic drugs and duration of anaesthesia vaned and depended on the type of breast surgery, determined by frozen section. Results: The mean ± SD dose of propofol required to produce loss of consciousness was 2.4 ± 0.6 mg · kg-1 and 2.0 ± 0.4 mg · kg-1 in the physostigmine and in the normal saline groups respectively (P = 0.014). Conclusion: Physostigmine pretreatment increases the dose of propofol required to produce loss of consciousness.
AB - Purpose: This prospective, randomized, double-blind study was performed to determine the effect of administration of physostigmine on the dose of propofol required to produce loss of consciousness. Methods: Forty female unpremedicated patients were assigned in a random blind design to receive either 2 mg physostigmine or equal volume of normal saline iv, five minutes before induction of anaesthesia with propofol. All patients received general anaesthesia for breast surgery. Propofol was infused at a constant rate of 200 ml · hr-1 while patients were breathing oxygen 100% via a face mask. In each patient the dose of propofol required to produce loss of the ability to grasp a 20 ml synnge was recorded as the end-point of loss of consciousness. At this point the protocol was terminated and, after intubation of the trachea, anaesthesia was maintained with a nitrous oxide-isoflurane or sevoflurane mixture in oxygen, increments of an opioid and a muscle relaxant. Doses of anaesthetic drugs and duration of anaesthesia vaned and depended on the type of breast surgery, determined by frozen section. Results: The mean ± SD dose of propofol required to produce loss of consciousness was 2.4 ± 0.6 mg · kg-1 and 2.0 ± 0.4 mg · kg-1 in the physostigmine and in the normal saline groups respectively (P = 0.014). Conclusion: Physostigmine pretreatment increases the dose of propofol required to produce loss of consciousness.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031450338&partnerID=8YFLogxK
U2 - 10.1007/BF03013335
DO - 10.1007/BF03013335
M3 - Article
C2 - 9398952
AN - SCOPUS:0031450338
VL - 44
SP - 1148
EP - 1151
JO - Canadian journal of anaesthesia = Journal canadien d'anesthésie
JF - Canadian journal of anaesthesia = Journal canadien d'anesthésie
SN - 0008-2856
IS - 11
ER -