Intravenous injection of sheep antiserum to somatostatin in the rat not only increases basal plasma TSH levels but also potentiates TSH response following exposure to cold (5°C). Plasma levels of GH rise 2-3 fold during the first 3 h after injection of the antiserum, with a progressive decrease of the effect up to 10 h. Rhythmical change of serum GH levels during a 10 hour period of observation is not altered after antiserum injection. These data indicate that somatostatin plays a physiological role in the control of both TSH and GH secretion and suggest the involvement of GH releasing hormone, in addition to somatostatin, in the GH release mechanism.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochemical and biophysical research communications|
|State||Published - Jan 12 1976|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology