Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion

Louise Ferland; Fernand Labrie; Michel Jobin; Akira Arimura; Andrew V. Schally

doi:10.1016/0006-291X(76)90022-X

Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion

Louise Ferland, Fernand Labrie, Michel Jobin, Akira Arimura, Andrew V. Schally

Research output: Contribution to journal › Article

222 Scopus citations

Abstract

Intravenous injection of sheep antiserum to somatostatin in the rat not only increases basal plasma TSH levels but also potentiates TSH response following exposure to cold (5°C). Plasma levels of GH rise 2-3 fold during the first 3 h after injection of the antiserum, with a progressive decrease of the effect up to 10 h. Rhythmical change of serum GH levels during a 10 hour period of observation is not altered after antiserum injection. These data indicate that somatostatin plays a physiological role in the control of both TSH and GH secretion and suggest the involvement of GH releasing hormone, in addition to somatostatin, in the GH release mechanism.

Original language	English (US)
Pages (from-to)	149-156
Number of pages	8
Journal	Biochemical and biophysical research communications
Volume	68
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(76)90022-X
State	Published - Jan 12 1976
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Ferland, L., Labrie, F., Jobin, M., Arimura, A., & Schally, A. V. (1976). Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion. Biochemical and biophysical research communications, 68(1), 149-156. https://doi.org/10.1016/0006-291X(76)90022-X

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