Abstract
Intravenous injection of sheep antiserum to somatostatin in the rat not only increases basal plasma TSH levels but also potentiates TSH response following exposure to cold (5°C). Plasma levels of GH rise 2-3 fold during the first 3 h after injection of the antiserum, with a progressive decrease of the effect up to 10 h. Rhythmical change of serum GH levels during a 10 hour period of observation is not altered after antiserum injection. These data indicate that somatostatin plays a physiological role in the control of both TSH and GH secretion and suggest the involvement of GH releasing hormone, in addition to somatostatin, in the GH release mechanism.
Original language | English (US) |
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Pages (from-to) | 149-156 |
Number of pages | 8 |
Journal | Biochemical and biophysical research communications |
Volume | 68 |
Issue number | 1 |
DOIs | |
State | Published - Jan 12 1976 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology