Physiological role of IL-15 and IL-18 at the maternal-fetal interface

Gordana Laskarin, Natasa Strbo, Tatjana Bogovic Crncic, Koraljka Juretic, Nathalie Ledee Bataille, Gerard Chaouat, Daniel Rukavina

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


We review recent studies of two cytokines IL-15 and IL-18, showing that they are the critical cytokines controlling uterine NK cell cytokine production and cytolytic potential. Further, IL-15 has been implicated in differentiation and proliferation of uterine NK cells, while IL-18 enhanced innate immunity and both Th1- and Th2-driven immune responses depending on the cytokine milieu. We addressed the possible role of these two cytokines in induction of the IFN-γ production as a key molecule in vascular remodeling during early pregnancy.

Original languageEnglish (US)
Pages (from-to)10-25
Number of pages16
JournalChemical Immunology and Allergy
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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