Physiological and biochemical effects of lithium in rainbow trout

Victoria Tkatcheva; Natasha M. Franklin; Grant B. McClelland; Richard W. Smith; Ismo J. Holopainen; Chris M. Wood

doi:10.1007/s00244-006-0173-5

Physiological and biochemical effects of lithium in rainbow trout

Victoria Tkatcheva, Natasha M. Franklin, Grant B. McClelland, Richard W. Smith, Ismo J. Holopainen, Chris M. Wood

Marine Biology and Fisheries

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The physiological responses of juvenile rainbow trout (Oncorhynchus mykiss) to lithium (as LiCl) in moderately hard freshwater (CaCO₃ = 120-140 ppm, Na⁺ = ∼0.6 mM) were studied. The study employed a 15-day step-up exposure regime; 66 μg/L Li for the first 9 days and 528 μg/L for the next 6 days. The concentrations of plasma ions, apolipoprotein AI, total cholesterol, and fatty acids, as well as metabolic enzyme citrate synthase (CS) and Na⁺,K⁺-ATPase activities in the gill were measured. Li affected fish by exacerbated diffusive Na⁺ losses at the gills in the beginning of exposure and a decrease of branchial CS activity. Detrimental effects were shown in fish exposed to 528 μg Li/L. These included a reduction of gill Na⁺,K⁺-ATPase activity, possibly related to observed lower concentrations of free fatty acids and cholesterol in gill tissue.

Original language	English (US)
Pages (from-to)	632-638
Number of pages	7
Journal	Archives of environmental contamination and toxicology
Volume	53
Issue number	4
DOIs	https://doi.org/10.1007/s00244-006-0173-5
State	Published - Nov 1 2007

Keywords

Apolipoprotein AI
Enzyme activity
Fish gill
Lipids
Lithium
Plasma ions

ASJC Scopus subject areas

Environmental Science(all)
Environmental Chemistry
Toxicology

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title = "Physiological and biochemical effects of lithium in rainbow trout",

abstract = "The physiological responses of juvenile rainbow trout (Oncorhynchus mykiss) to lithium (as LiCl) in moderately hard freshwater (CaCO3 = 120-140 ppm, Na+ = ∼0.6 mM) were studied. The study employed a 15-day step-up exposure regime; 66 μg/L Li for the first 9 days and 528 μg/L for the next 6 days. The concentrations of plasma ions, apolipoprotein AI, total cholesterol, and fatty acids, as well as metabolic enzyme citrate synthase (CS) and Na+,K+-ATPase activities in the gill were measured. Li affected fish by exacerbated diffusive Na+ losses at the gills in the beginning of exposure and a decrease of branchial CS activity. Detrimental effects were shown in fish exposed to 528 μg Li/L. These included a reduction of gill Na+,K+-ATPase activity, possibly related to observed lower concentrations of free fatty acids and cholesterol in gill tissue.",

keywords = "Apolipoprotein AI, Enzyme activity, Fish gill, Lipids, Lithium, Plasma ions",

author = "Victoria Tkatcheva and Franklin, {Natasha M.} and McClelland, {Grant B.} and Smith, {Richard W.} and Holopainen, {Ismo J.} and Wood, {Chris M.}",

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AU - Tkatcheva, Victoria

AU - Franklin, Natasha M.

AU - McClelland, Grant B.

AU - Smith, Richard W.

AU - Holopainen, Ismo J.

AU - Wood, Chris M.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - The physiological responses of juvenile rainbow trout (Oncorhynchus mykiss) to lithium (as LiCl) in moderately hard freshwater (CaCO3 = 120-140 ppm, Na+ = ∼0.6 mM) were studied. The study employed a 15-day step-up exposure regime; 66 μg/L Li for the first 9 days and 528 μg/L for the next 6 days. The concentrations of plasma ions, apolipoprotein AI, total cholesterol, and fatty acids, as well as metabolic enzyme citrate synthase (CS) and Na+,K+-ATPase activities in the gill were measured. Li affected fish by exacerbated diffusive Na+ losses at the gills in the beginning of exposure and a decrease of branchial CS activity. Detrimental effects were shown in fish exposed to 528 μg Li/L. These included a reduction of gill Na+,K+-ATPase activity, possibly related to observed lower concentrations of free fatty acids and cholesterol in gill tissue.

AB - The physiological responses of juvenile rainbow trout (Oncorhynchus mykiss) to lithium (as LiCl) in moderately hard freshwater (CaCO3 = 120-140 ppm, Na+ = ∼0.6 mM) were studied. The study employed a 15-day step-up exposure regime; 66 μg/L Li for the first 9 days and 528 μg/L for the next 6 days. The concentrations of plasma ions, apolipoprotein AI, total cholesterol, and fatty acids, as well as metabolic enzyme citrate synthase (CS) and Na+,K+-ATPase activities in the gill were measured. Li affected fish by exacerbated diffusive Na+ losses at the gills in the beginning of exposure and a decrease of branchial CS activity. Detrimental effects were shown in fish exposed to 528 μg Li/L. These included a reduction of gill Na+,K+-ATPase activity, possibly related to observed lower concentrations of free fatty acids and cholesterol in gill tissue.

KW - Apolipoprotein AI

KW - Enzyme activity

KW - Fish gill

KW - Lipids

KW - Lithium

KW - Plasma ions

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