Physiological and biochemical effects of lithium in rainbow trout

Victoria Tkatcheva, Natasha M. Franklin, Grant B. McClelland, Richard W. Smith, Ismo J. Holopainen, Chris M. Wood

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The physiological responses of juvenile rainbow trout (Oncorhynchus mykiss) to lithium (as LiCl) in moderately hard freshwater (CaCO3 = 120-140 ppm, Na+ = ∼0.6 mM) were studied. The study employed a 15-day step-up exposure regime; 66 μg/L Li for the first 9 days and 528 μg/L for the next 6 days. The concentrations of plasma ions, apolipoprotein AI, total cholesterol, and fatty acids, as well as metabolic enzyme citrate synthase (CS) and Na+,K+-ATPase activities in the gill were measured. Li affected fish by exacerbated diffusive Na+ losses at the gills in the beginning of exposure and a decrease of branchial CS activity. Detrimental effects were shown in fish exposed to 528 μg Li/L. These included a reduction of gill Na+,K+-ATPase activity, possibly related to observed lower concentrations of free fatty acids and cholesterol in gill tissue.

Original languageEnglish (US)
Pages (from-to)632-638
Number of pages7
JournalArchives of environmental contamination and toxicology
Issue number4
StatePublished - Nov 1 2007


  • Apolipoprotein AI
  • Enzyme activity
  • Fish gill
  • Lipids
  • Lithium
  • Plasma ions

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Toxicology


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