TY - JOUR
T1 - Physics considerations in targeted anticancer drug delivery by magnetoelectric nanoparticles
AU - Stimphil, Emmanuel
AU - Nagesetti, Abhignyan
AU - Guduru, Rakesh
AU - Stewart, Tiffanie
AU - Rodzinski, Alexandra
AU - Liang, Ping
AU - Khizroev, Sakhrat
N1 - Funding Information:
We acknowledge partial financial support from National Science Foundation (NSF) Award Nos. ECCS-1408063 (S.K.), ECCS-0939514 (S.K.), and IIP-1237818 (S.K.), National Institutes of Health (NIH) DA Nos. R01DA034547-01 (S.K.) and NIGMS R25 GM061347 (E.S.), and Neuroscience Centers of Florida Foundation (NSCFF) (S.K.). We thank Dr. Carolyn Runowicz, Dr. Andrew Schally, and Dr. Seza Gulec for many insightful and inspiring discussions on cancer research. We thank Bassim Arkook and Dr. Mikhail Itkis for their invaluable help with cryogenic VSM measurements.
Publisher Copyright:
© 2017 Author(s).
PY - 2017/6/1
Y1 - 2017/6/1
N2 - In regard to cancer therapy, magnetoelectric nanoparticles (MENs) have proven to be in a class of its own when compared to any other nanoparticle type. Like conventional magnetic nanoparticles, they can be used for externally controlled drug delivery via application of a magnetic field gradient and image-guided delivery. However, unlike conventional nanoparticles, due to the presence of a non-zero magnetoelectric effect, MENs provide a unique mix of important properties to address key challenges in modern cancer therapy: (i) a targeting mechanism driven by a physical force rather than antibody matching, (ii) a high-specificity delivery to enhance the cellular uptake of therapeutic drugs across the cancer cell membranes only, while sparing normal cells, (iii) an externally controlled mechanism to release drugs on demand, and (iv) a capability for image guided precision medicine. These properties separate MEN-based targeted delivery from traditional biotechnology approaches and lay a foundation for the complementary approach of technobiology. The biotechnology approach stems from the underlying biology and exploits bioinformatics to find the right therapy. In contrast, the technobiology approach is geared towards using the physics of molecular-level interactions between cells and nanoparticles to treat cancer at the most fundamental level and thus can be extended to all the cancers. This paper gives an overview of the current state of the art and presents an ab initio model to describe the underlying mechanisms of cancer treatment with MENs from the perspective of basic physics.
AB - In regard to cancer therapy, magnetoelectric nanoparticles (MENs) have proven to be in a class of its own when compared to any other nanoparticle type. Like conventional magnetic nanoparticles, they can be used for externally controlled drug delivery via application of a magnetic field gradient and image-guided delivery. However, unlike conventional nanoparticles, due to the presence of a non-zero magnetoelectric effect, MENs provide a unique mix of important properties to address key challenges in modern cancer therapy: (i) a targeting mechanism driven by a physical force rather than antibody matching, (ii) a high-specificity delivery to enhance the cellular uptake of therapeutic drugs across the cancer cell membranes only, while sparing normal cells, (iii) an externally controlled mechanism to release drugs on demand, and (iv) a capability for image guided precision medicine. These properties separate MEN-based targeted delivery from traditional biotechnology approaches and lay a foundation for the complementary approach of technobiology. The biotechnology approach stems from the underlying biology and exploits bioinformatics to find the right therapy. In contrast, the technobiology approach is geared towards using the physics of molecular-level interactions between cells and nanoparticles to treat cancer at the most fundamental level and thus can be extended to all the cancers. This paper gives an overview of the current state of the art and presents an ab initio model to describe the underlying mechanisms of cancer treatment with MENs from the perspective of basic physics.
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U2 - 10.1063/1.4978642
DO - 10.1063/1.4978642
M3 - Review article
AN - SCOPUS:85017091585
VL - 4
JO - Applied Physics Reviews
JF - Applied Physics Reviews
SN - 1931-9401
IS - 2
M1 - 021101
ER -