Physical properties and biodegradation of lactide-based poly(ethylene glycol) polymer networks for tissue engineering

Young Min Ju, Kwang Duk Ahn, Jong Man Kim, Jeffrey A. Hubbell, Dong Keun Han

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

New lactide-based poly(ethylene glycol) (PEG) polymer networks (GL-PEG) have been prepared by photopolymerization using two nontoxic macromers, triacrylated lactic acid oligomer emanating from a glycerol center (GL) and monoacrylated PEG. These materials may use as polymer scaffolds in tissue engineering because they provide biodegradable, cell-adhesion resistant, and ligand-immobilizable characteristics. The thermal and mechanical properties of the resulting GL-PEG networks were evaluated and their biodegradability was investigated in phosphate buffered saline (PBS) at 80°C. The glass transition temperature (Tg) of all networks after degradation relatively decreased and the trend was similar to those before biodegradation, whereas thermal decomposition temperature (Td1/2) increased in all networks to a certain degree. The tensile strength decreased as PEG was incorporated and as the molecular weight and content of PEG increased due to the soft PEG chains. Degradation rate of GL-PEG networks was controlled by the ratio of GL to PEG, and generally the rate of GL-PEG networks was faster than that of GL homonetworks.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalPolymer Bulletin
Volume50
Issue number1-2
DOIs
StatePublished - Apr 1 2003

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Polymers and Plastics
  • Materials Chemistry

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