Physical Inactivity Predicts Slow Gait Speed in an Elderly Multi-Ethnic Cohort Study: The Northern Manhattan Study

Joshua Z. Willey, Yeseon P. Moon, Erin R. Kulick, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Mitchell S.V. Elkind

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: Gait speed is associated with multiple adverse outcomes of aging. We hypothesized that physical inactivity would be prospectively inversely associated with gait speed independently of white matter hyperintensity volume and silent brain infarcts on MRI. Methods: Participants in the Northern Manhattan Study MRI sub-study had physical activity assessed when they were enrolled into the study. A mean of 5 years after the MRI, participants had gait speed measured via a timed 5-meter walk test. Physical inactivity was defined as reporting no leisure-time physical activity. Multi-variable logistic and quantile regression was performed to examine the associations between physical inactivity and future gait speed adjusted for confounders. Results: Among 711 participants with MRI and gait speed measures (62% women, 71% Hispanic, mean age 74.1 ± 8.4), the mean gait speed was 1.02 ± 0.26 m/s. Physical inactivity was associated with a greater odds of gait speed in the lowest quartile (<0.85 m/s, adjusted OR 1.90, 95% CI 1.17-3.08), and in quantile regression with 0.06 m/s slower gait speed at the lowest 20 percentile (p = 0.005). Conclusions: Physical inactivity is associated with slower gait speed independently of osteoarthritis, grip strength, and subclinical ischemic brain injury. Modifying sedentary behavior poses a target for interventions aimed at reducing decline in mobility.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalNeuroepidemiology
DOIs
StateAccepted/In press - Aug 16 2017

Fingerprint

Cohort Studies
Exercise
Walking Speed
Leisure Activities
Hand Strength
Hispanic Americans
Osteoarthritis
Brain Injuries
Logistic Models
Brain

Keywords

  • Elderly
  • Gait speed
  • Magnetic resonance imaging
  • Mobility
  • Physical activity
  • Subclinical stroke

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

Cite this

Willey, J. Z., Moon, Y. P., Kulick, E. R., Cheung, Y. K., Wright, C. B., Sacco, R. L., & Elkind, M. S. V. (Accepted/In press). Physical Inactivity Predicts Slow Gait Speed in an Elderly Multi-Ethnic Cohort Study: The Northern Manhattan Study. Neuroepidemiology, 24-30. https://doi.org/10.1159/000479695

Physical Inactivity Predicts Slow Gait Speed in an Elderly Multi-Ethnic Cohort Study : The Northern Manhattan Study. / Willey, Joshua Z.; Moon, Yeseon P.; Kulick, Erin R.; Cheung, Ying Kuen; Wright, Clinton B; Sacco, Ralph L; Elkind, Mitchell S.V.

In: Neuroepidemiology, 16.08.2017, p. 24-30.

Research output: Contribution to journalArticle

Willey, Joshua Z. ; Moon, Yeseon P. ; Kulick, Erin R. ; Cheung, Ying Kuen ; Wright, Clinton B ; Sacco, Ralph L ; Elkind, Mitchell S.V. / Physical Inactivity Predicts Slow Gait Speed in an Elderly Multi-Ethnic Cohort Study : The Northern Manhattan Study. In: Neuroepidemiology. 2017 ; pp. 24-30.
@article{a17e4005e35f49a68f5aad54a15f9182,
title = "Physical Inactivity Predicts Slow Gait Speed in an Elderly Multi-Ethnic Cohort Study: The Northern Manhattan Study",
abstract = "Introduction: Gait speed is associated with multiple adverse outcomes of aging. We hypothesized that physical inactivity would be prospectively inversely associated with gait speed independently of white matter hyperintensity volume and silent brain infarcts on MRI. Methods: Participants in the Northern Manhattan Study MRI sub-study had physical activity assessed when they were enrolled into the study. A mean of 5 years after the MRI, participants had gait speed measured via a timed 5-meter walk test. Physical inactivity was defined as reporting no leisure-time physical activity. Multi-variable logistic and quantile regression was performed to examine the associations between physical inactivity and future gait speed adjusted for confounders. Results: Among 711 participants with MRI and gait speed measures (62{\%} women, 71{\%} Hispanic, mean age 74.1 ± 8.4), the mean gait speed was 1.02 ± 0.26 m/s. Physical inactivity was associated with a greater odds of gait speed in the lowest quartile (<0.85 m/s, adjusted OR 1.90, 95{\%} CI 1.17-3.08), and in quantile regression with 0.06 m/s slower gait speed at the lowest 20 percentile (p = 0.005). Conclusions: Physical inactivity is associated with slower gait speed independently of osteoarthritis, grip strength, and subclinical ischemic brain injury. Modifying sedentary behavior poses a target for interventions aimed at reducing decline in mobility.",
keywords = "Elderly, Gait speed, Magnetic resonance imaging, Mobility, Physical activity, Subclinical stroke",
author = "Willey, {Joshua Z.} and Moon, {Yeseon P.} and Kulick, {Erin R.} and Cheung, {Ying Kuen} and Wright, {Clinton B} and Sacco, {Ralph L} and Elkind, {Mitchell S.V.}",
year = "2017",
month = "8",
day = "16",
doi = "10.1159/000479695",
language = "English (US)",
pages = "24--30",
journal = "Neuroepidemiology",
issn = "0251-5350",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - Physical Inactivity Predicts Slow Gait Speed in an Elderly Multi-Ethnic Cohort Study

T2 - The Northern Manhattan Study

AU - Willey, Joshua Z.

AU - Moon, Yeseon P.

AU - Kulick, Erin R.

AU - Cheung, Ying Kuen

AU - Wright, Clinton B

AU - Sacco, Ralph L

AU - Elkind, Mitchell S.V.

PY - 2017/8/16

Y1 - 2017/8/16

N2 - Introduction: Gait speed is associated with multiple adverse outcomes of aging. We hypothesized that physical inactivity would be prospectively inversely associated with gait speed independently of white matter hyperintensity volume and silent brain infarcts on MRI. Methods: Participants in the Northern Manhattan Study MRI sub-study had physical activity assessed when they were enrolled into the study. A mean of 5 years after the MRI, participants had gait speed measured via a timed 5-meter walk test. Physical inactivity was defined as reporting no leisure-time physical activity. Multi-variable logistic and quantile regression was performed to examine the associations between physical inactivity and future gait speed adjusted for confounders. Results: Among 711 participants with MRI and gait speed measures (62% women, 71% Hispanic, mean age 74.1 ± 8.4), the mean gait speed was 1.02 ± 0.26 m/s. Physical inactivity was associated with a greater odds of gait speed in the lowest quartile (<0.85 m/s, adjusted OR 1.90, 95% CI 1.17-3.08), and in quantile regression with 0.06 m/s slower gait speed at the lowest 20 percentile (p = 0.005). Conclusions: Physical inactivity is associated with slower gait speed independently of osteoarthritis, grip strength, and subclinical ischemic brain injury. Modifying sedentary behavior poses a target for interventions aimed at reducing decline in mobility.

AB - Introduction: Gait speed is associated with multiple adverse outcomes of aging. We hypothesized that physical inactivity would be prospectively inversely associated with gait speed independently of white matter hyperintensity volume and silent brain infarcts on MRI. Methods: Participants in the Northern Manhattan Study MRI sub-study had physical activity assessed when they were enrolled into the study. A mean of 5 years after the MRI, participants had gait speed measured via a timed 5-meter walk test. Physical inactivity was defined as reporting no leisure-time physical activity. Multi-variable logistic and quantile regression was performed to examine the associations between physical inactivity and future gait speed adjusted for confounders. Results: Among 711 participants with MRI and gait speed measures (62% women, 71% Hispanic, mean age 74.1 ± 8.4), the mean gait speed was 1.02 ± 0.26 m/s. Physical inactivity was associated with a greater odds of gait speed in the lowest quartile (<0.85 m/s, adjusted OR 1.90, 95% CI 1.17-3.08), and in quantile regression with 0.06 m/s slower gait speed at the lowest 20 percentile (p = 0.005). Conclusions: Physical inactivity is associated with slower gait speed independently of osteoarthritis, grip strength, and subclinical ischemic brain injury. Modifying sedentary behavior poses a target for interventions aimed at reducing decline in mobility.

KW - Elderly

KW - Gait speed

KW - Magnetic resonance imaging

KW - Mobility

KW - Physical activity

KW - Subclinical stroke

UR - http://www.scopus.com/inward/record.url?scp=85027683321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027683321&partnerID=8YFLogxK

U2 - 10.1159/000479695

DO - 10.1159/000479695

M3 - Article

C2 - 28810247

AN - SCOPUS:85027683321

SP - 24

EP - 30

JO - Neuroepidemiology

JF - Neuroepidemiology

SN - 0251-5350

ER -