Abstract
Obesity, sedentary lifestyles, and antiretroviral therapies may predispose HIV-infected children to poor physical fitness. Estimated peak oxygen consumption (VO2 peak), maximal strength and endurance, and flexibility were measured in HIV-infected and uninfected children. Among HIV-infected children, anthropometric and HIV disease-specific factors were evaluated to determine their association with VO2 peak. Forty-five HIV-infected children (mean age 16.1 years) and 36 uninfected children (mean age 13.5 years) participated in the study. In HIV-infected subjects, median viral load was 980 copies/ml (IQR 200-11,000 copies/ml), CD4% was 28% (IQR 15-35%), and 82% were on highly active antiretroviral therapy (HAART). Compared to uninfected children, after adjusting for age, sex, race, body fat, and siblingship, HIV-infected children had lower VO2 peak (25.92 vs. 30.90 ml/kg/min, p<0.0001), flexibility (23.71% vs. 46.09%, p=0.0003), and lower-extremity strength-to-weight ratio (0.79 vs. 1.10 kg lifted/kg of body weight, p=0.002). Among the HIV-infected children, a multivariable analysis adjusting for age, sex, race, percent body fat, and viral load showed VO 2 peak was 0.30 ml/kg/min lower per unit increase in percent body fat (p<0.0001) and VO2 peak (SE) decreased 29.45 (±1.62), 28.70 (±1.87), and 24.09 (±0.75) ml/kg/min across HAART exposure categories of no exposure, <60, and ≥60 months, respectively (p<0.0001). HIV-infected children had, in general, lower measures of fitness compared to uninfected children. Factors negatively associated with VO 2 peak in HIV-infected children include higher body fat and duration of HAART ≥60 months. Future studies that elucidate the understanding of these differences and mechanisms of decreased physical fitness should be pursued.
| Original language | English |
|---|---|
| Pages (from-to) | 112-120 |
| Number of pages | 9 |
| Journal | AIDS Research and Human Retroviruses |
| Volume | 29 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2013 |
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ASJC Scopus subject areas
- Immunology
- Virology
- Infectious Diseases
Cite this
Physical fitness in children infected with the human immunodeficiency virus : Associations with highly active antiretroviral therapy. / Somarriba, Gabriel; Lopez-Mitnik, Gabriela; Ludwig, David; Neri, Daniela; Schaefer, Natasha; Lipshultz, Steven E; Scott, Gwendolyn B; Miller, Tracie L.
In: AIDS Research and Human Retroviruses, Vol. 29, No. 1, 01.01.2013, p. 112-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Physical fitness in children infected with the human immunodeficiency virus
T2 - Associations with highly active antiretroviral therapy
AU - Somarriba, Gabriel
AU - Lopez-Mitnik, Gabriela
AU - Ludwig, David
AU - Neri, Daniela
AU - Schaefer, Natasha
AU - Lipshultz, Steven E
AU - Scott, Gwendolyn B
AU - Miller, Tracie L
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Obesity, sedentary lifestyles, and antiretroviral therapies may predispose HIV-infected children to poor physical fitness. Estimated peak oxygen consumption (VO2 peak), maximal strength and endurance, and flexibility were measured in HIV-infected and uninfected children. Among HIV-infected children, anthropometric and HIV disease-specific factors were evaluated to determine their association with VO2 peak. Forty-five HIV-infected children (mean age 16.1 years) and 36 uninfected children (mean age 13.5 years) participated in the study. In HIV-infected subjects, median viral load was 980 copies/ml (IQR 200-11,000 copies/ml), CD4% was 28% (IQR 15-35%), and 82% were on highly active antiretroviral therapy (HAART). Compared to uninfected children, after adjusting for age, sex, race, body fat, and siblingship, HIV-infected children had lower VO2 peak (25.92 vs. 30.90 ml/kg/min, p<0.0001), flexibility (23.71% vs. 46.09%, p=0.0003), and lower-extremity strength-to-weight ratio (0.79 vs. 1.10 kg lifted/kg of body weight, p=0.002). Among the HIV-infected children, a multivariable analysis adjusting for age, sex, race, percent body fat, and viral load showed VO 2 peak was 0.30 ml/kg/min lower per unit increase in percent body fat (p<0.0001) and VO2 peak (SE) decreased 29.45 (±1.62), 28.70 (±1.87), and 24.09 (±0.75) ml/kg/min across HAART exposure categories of no exposure, <60, and ≥60 months, respectively (p<0.0001). HIV-infected children had, in general, lower measures of fitness compared to uninfected children. Factors negatively associated with VO 2 peak in HIV-infected children include higher body fat and duration of HAART ≥60 months. Future studies that elucidate the understanding of these differences and mechanisms of decreased physical fitness should be pursued.
AB - Obesity, sedentary lifestyles, and antiretroviral therapies may predispose HIV-infected children to poor physical fitness. Estimated peak oxygen consumption (VO2 peak), maximal strength and endurance, and flexibility were measured in HIV-infected and uninfected children. Among HIV-infected children, anthropometric and HIV disease-specific factors were evaluated to determine their association with VO2 peak. Forty-five HIV-infected children (mean age 16.1 years) and 36 uninfected children (mean age 13.5 years) participated in the study. In HIV-infected subjects, median viral load was 980 copies/ml (IQR 200-11,000 copies/ml), CD4% was 28% (IQR 15-35%), and 82% were on highly active antiretroviral therapy (HAART). Compared to uninfected children, after adjusting for age, sex, race, body fat, and siblingship, HIV-infected children had lower VO2 peak (25.92 vs. 30.90 ml/kg/min, p<0.0001), flexibility (23.71% vs. 46.09%, p=0.0003), and lower-extremity strength-to-weight ratio (0.79 vs. 1.10 kg lifted/kg of body weight, p=0.002). Among the HIV-infected children, a multivariable analysis adjusting for age, sex, race, percent body fat, and viral load showed VO 2 peak was 0.30 ml/kg/min lower per unit increase in percent body fat (p<0.0001) and VO2 peak (SE) decreased 29.45 (±1.62), 28.70 (±1.87), and 24.09 (±0.75) ml/kg/min across HAART exposure categories of no exposure, <60, and ≥60 months, respectively (p<0.0001). HIV-infected children had, in general, lower measures of fitness compared to uninfected children. Factors negatively associated with VO 2 peak in HIV-infected children include higher body fat and duration of HAART ≥60 months. Future studies that elucidate the understanding of these differences and mechanisms of decreased physical fitness should be pursued.
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UR - http://www.scopus.com/inward/citedby.url?scp=84871907016&partnerID=8YFLogxK
U2 - 10.1089/aid.2012.0047
DO - 10.1089/aid.2012.0047
M3 - Article
C2 - 22747252
AN - SCOPUS:84871907016
VL - 29
SP - 112
EP - 120
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 1
ER -