Physical activity and health outcomes among HIV-infected men who have sex with men: A longitudinal mediational analysis

Aaron J. Blashill, Kenneth H. Mayer, Heidi Crane, Jessica F. Magidson, Chris Grasso, W. Christopher Mathews, Michael S. Saag, Steven A. Safren

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: Low physical activity is associated with depression, which may, in turn, negatively impact antiretroviral therapy (ART) adherence among HIV-infected individuals; however, prior studies have not investigated the relationships between physical inactivity and ART non-adherence. Purpose: The purpose of this study was to examine the association of physical inactivity, depression, ART non-adherence, and viral load in HIV-infected men who have sex with men. Methods: The sample (N = 860) was from a large, multicenter cohort of HIV-infected patients engaged in clinical care. Results: Across time, depression mediated the relationship between physical inactivity and ART non-adherence (γ = 0.075) and the relationship between physical inactivity and viral load (γ = 0.05). ART non-adherence mediated the relationship between depression and viral load (γ = 0.002) and the relationship between physical inactivity and viral load (γ = 0.009). Conclusions: Low levels of physical activity predicted increased depression and poor ART adherence over time, which subsequently predicted higher viral load.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalAnnals of Behavioral Medicine
Volume46
Issue number2
DOIs
StatePublished - Oct 2013

Keywords

  • Adherence
  • Depression
  • HIV/AIDS
  • Physical activity
  • Viral load

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health

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