Photosensitizer in a molecular bowl: Steric protection enhancing the photonuclease activity of copper(II) scorpionates

Shanta Dhar; Akhil R. Chakravarty

doi:10.1021/ic050085a

Photosensitizer in a molecular bowl: Steric protection enhancing the photonuclease activity of copper(II) scorpionates

Shanta Dhar, Akhil R. Chakravarty

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Steric encumbrance caused by the tripodal ligand in the ternary tris(3-phenylpyrazolyl)borate copper(II) heterocyclic base complexes [Cu(B)(Tp^Ph)](ClIO₄) (B = dipyridoquinoxaline, dipyridophenazine) leads to efficient cleavage of supercoiled DNA to its relaxed form upon exposure to red light at 632.8 and 694 nm as a result of protection of the photosensitizer in the molecular bowl of the {Cu(Tp^Ph)} moiety, which generates singlet oxygen as the reactive species in a type-II process.

Original language	English (US)
Pages (from-to)	2582-2584
Number of pages	3
Journal	Inorganic Chemistry
Volume	44
Issue number	8
DOIs	https://doi.org/10.1021/ic050085a
State	Published - Apr 18 2005
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

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10.1021/ic050085a

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title = "Photosensitizer in a molecular bowl: Steric protection enhancing the photonuclease activity of copper(II) scorpionates",

abstract = "Steric encumbrance caused by the tripodal ligand in the ternary tris(3-phenylpyrazolyl)borate copper(II) heterocyclic base complexes [Cu(B)(TpPh)](ClIO4) (B = dipyridoquinoxaline, dipyridophenazine) leads to efficient cleavage of supercoiled DNA to its relaxed form upon exposure to red light at 632.8 and 694 nm as a result of protection of the photosensitizer in the molecular bowl of the {Cu(TpPh)} moiety, which generates singlet oxygen as the reactive species in a type-II process.",

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AB - Steric encumbrance caused by the tripodal ligand in the ternary tris(3-phenylpyrazolyl)borate copper(II) heterocyclic base complexes [Cu(B)(TpPh)](ClIO4) (B = dipyridoquinoxaline, dipyridophenazine) leads to efficient cleavage of supercoiled DNA to its relaxed form upon exposure to red light at 632.8 and 694 nm as a result of protection of the photosensitizer in the molecular bowl of the {Cu(TpPh)} moiety, which generates singlet oxygen as the reactive species in a type-II process.

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Photosensitizer in a molecular bowl: Steric protection enhancing the photonuclease activity of copper(II) scorpionates

Abstract

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