Photoreceptor protection by mesencephalic astrocyte-derived neurotrophic factor (MANF)

Jianmin Lu, Lingyu Luo, Deqiang Huang, Xian Liu, Xin Xia, Zhengying Wang, Byron L Lam, Jinglin Yi, Rong Wen, Yiwen Li

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Retinal degenerations are a major cause of vision impairment and blindness. Neuroprotective therapy is a promising therapeutic strategy for retinal degenerative diseases.We investigated a novel neurotrophic factormesencephalicastrocyte-derived neurotrophic factor (MANF) in the retina. MANF is expressed at a high level during postnatal development and the expression declines to a lower level as the retina matures. Müller cells are the major cells expressing MANF. It is also found in the retinal ganglion cells, in the inner nuclear layer (INL) neurons, and in retinal pigment epithelial (RPE) cells. Intravitreal injection of recombinant human (rh)MANF significantly protected rod and cone photoreceptors in rats carrying the rhodopsin S334ter mutation, and preserved electroretinograms (ERGs) in the rd10 (Pde6brd10/rd10) mice. These results indicate that MANF is a native protein in the retina and is a potent neurotrophic factor for photoreceptor protection.

Original languageEnglish (US)
Article numbere0109-18.2018
JournaleNeuro
Volume5
Issue number2
DOIs
StatePublished - Mar 1 2018

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Nerve Growth Factors
Astrocytes
Retina
Retinal Cone Photoreceptor Cells
Retinal Rod Photoreceptor Cells
Retinal Diseases
Retinal Degeneration
Vertebrate Photoreceptor Cells
Intravitreal Injections
Retinal Pigments
Rhodopsin
Retinal Ganglion Cells
Blindness
Epithelial Cells
Neurons
Mutation
Therapeutics
Proteins

Keywords

  • Degeneration
  • MANF
  • Neuroprotection
  • Photoreceptor
  • Retina
  • RGC

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Photoreceptor protection by mesencephalic astrocyte-derived neurotrophic factor (MANF). / Lu, Jianmin; Luo, Lingyu; Huang, Deqiang; Liu, Xian; Xia, Xin; Wang, Zhengying; Lam, Byron L; Yi, Jinglin; Wen, Rong; Li, Yiwen.

In: eNeuro, Vol. 5, No. 2, e0109-18.2018, 01.03.2018.

Research output: Contribution to journalArticle

Lu, Jianmin ; Luo, Lingyu ; Huang, Deqiang ; Liu, Xian ; Xia, Xin ; Wang, Zhengying ; Lam, Byron L ; Yi, Jinglin ; Wen, Rong ; Li, Yiwen. / Photoreceptor protection by mesencephalic astrocyte-derived neurotrophic factor (MANF). In: eNeuro. 2018 ; Vol. 5, No. 2.
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