Photoreceptor degeneration is correlated with the deterioration of macular retinal sensitivity in high myopia

Yuanyuan Wang, Jie Ye, Meixiao Shen, Aixia Yao, Anquan Xue, Yuchen Fan, Shenghai Huang, Jianhua Wang, Fan Lu, Yilei Shao

Research output: Contribution to journalArticle

Abstract

PURPOSE. To investigate structural changes in the retinal outer layers and choroid using adaptive optics (AO) and optical coherence tomography (OCT) in eyes with myopia, and to correlate the changes with decreased macular light sensitivity (MLS). METHODS. This prospective study included 27 subjects with emmetropia and low myopia (EM/LM), 25 with moderate myopia (MM), and 25 with high myopia (HM). Microperimetry was used to quantify MLS in each subject, while AO and OCT images of fundus were analyzed to quantify cone density and regularity and thickness of outer retinal sublayers and choroid. Differences of MLS, cone distribution, and chorioretinal thicknesses were compared among the three groups, and the associations among photoreceptor morphological alterations, MLS, and other parameters were analyzed. RESULTS. In HM, the MLS, cone density and regularity, and thicknesses of the myoid and ellipsoid zone (MEZ), Henle fiber layer and outer nuclear layer, interdigitation zone and RPE/Bruch complex, and choroid were lower than in EM/LM. Decreased MLS was correlated with lower cone density and regularity, and thinner MEZ and choroid in the inner region, and with lower cone density, thinner MEZ and choroid, and longer axial length in the outer region. Multivariate regression showed that better MLS was correlated with thicker MEZ in the inner region and with higher cone density in the outer region. CONCLUSIONS. Altered cone distribution and outer retinal thickness, especially cone density and MEZ thickness, were significantly correlated with decline of MLS in HM, which may help to evaluate and monitor visual impairment in HM.

Original languageEnglish (US)
Pages (from-to)2800-2810
Number of pages11
JournalInvestigative Ophthalmology and Visual Science
Volume60
Issue number8
DOIs
StatePublished - Jul 2019

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Photophobia
Myopia
Choroid
Emmetropia
Optical Coherence Tomography
Vision Disorders
Prospective Studies

Keywords

  • Adaptive optics
  • High myopia
  • Macular retinal sensitivity
  • Optical coherence tomography
  • Photoreceptor degeneration

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Photoreceptor degeneration is correlated with the deterioration of macular retinal sensitivity in high myopia. / Wang, Yuanyuan; Ye, Jie; Shen, Meixiao; Yao, Aixia; Xue, Anquan; Fan, Yuchen; Huang, Shenghai; Wang, Jianhua; Lu, Fan; Shao, Yilei.

In: Investigative Ophthalmology and Visual Science, Vol. 60, No. 8, 07.2019, p. 2800-2810.

Research output: Contribution to journalArticle

Wang, Yuanyuan ; Ye, Jie ; Shen, Meixiao ; Yao, Aixia ; Xue, Anquan ; Fan, Yuchen ; Huang, Shenghai ; Wang, Jianhua ; Lu, Fan ; Shao, Yilei. / Photoreceptor degeneration is correlated with the deterioration of macular retinal sensitivity in high myopia. In: Investigative Ophthalmology and Visual Science. 2019 ; Vol. 60, No. 8. pp. 2800-2810.
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abstract = "PURPOSE. To investigate structural changes in the retinal outer layers and choroid using adaptive optics (AO) and optical coherence tomography (OCT) in eyes with myopia, and to correlate the changes with decreased macular light sensitivity (MLS). METHODS. This prospective study included 27 subjects with emmetropia and low myopia (EM/LM), 25 with moderate myopia (MM), and 25 with high myopia (HM). Microperimetry was used to quantify MLS in each subject, while AO and OCT images of fundus were analyzed to quantify cone density and regularity and thickness of outer retinal sublayers and choroid. Differences of MLS, cone distribution, and chorioretinal thicknesses were compared among the three groups, and the associations among photoreceptor morphological alterations, MLS, and other parameters were analyzed. RESULTS. In HM, the MLS, cone density and regularity, and thicknesses of the myoid and ellipsoid zone (MEZ), Henle fiber layer and outer nuclear layer, interdigitation zone and RPE/Bruch complex, and choroid were lower than in EM/LM. Decreased MLS was correlated with lower cone density and regularity, and thinner MEZ and choroid in the inner region, and with lower cone density, thinner MEZ and choroid, and longer axial length in the outer region. Multivariate regression showed that better MLS was correlated with thicker MEZ in the inner region and with higher cone density in the outer region. CONCLUSIONS. Altered cone distribution and outer retinal thickness, especially cone density and MEZ thickness, were significantly correlated with decline of MLS in HM, which may help to evaluate and monitor visual impairment in HM.",
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AU - Wang, Yuanyuan

AU - Ye, Jie

AU - Shen, Meixiao

AU - Yao, Aixia

AU - Xue, Anquan

AU - Fan, Yuchen

AU - Huang, Shenghai

AU - Wang, Jianhua

AU - Lu, Fan

AU - Shao, Yilei

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N2 - PURPOSE. To investigate structural changes in the retinal outer layers and choroid using adaptive optics (AO) and optical coherence tomography (OCT) in eyes with myopia, and to correlate the changes with decreased macular light sensitivity (MLS). METHODS. This prospective study included 27 subjects with emmetropia and low myopia (EM/LM), 25 with moderate myopia (MM), and 25 with high myopia (HM). Microperimetry was used to quantify MLS in each subject, while AO and OCT images of fundus were analyzed to quantify cone density and regularity and thickness of outer retinal sublayers and choroid. Differences of MLS, cone distribution, and chorioretinal thicknesses were compared among the three groups, and the associations among photoreceptor morphological alterations, MLS, and other parameters were analyzed. RESULTS. In HM, the MLS, cone density and regularity, and thicknesses of the myoid and ellipsoid zone (MEZ), Henle fiber layer and outer nuclear layer, interdigitation zone and RPE/Bruch complex, and choroid were lower than in EM/LM. Decreased MLS was correlated with lower cone density and regularity, and thinner MEZ and choroid in the inner region, and with lower cone density, thinner MEZ and choroid, and longer axial length in the outer region. Multivariate regression showed that better MLS was correlated with thicker MEZ in the inner region and with higher cone density in the outer region. CONCLUSIONS. Altered cone distribution and outer retinal thickness, especially cone density and MEZ thickness, were significantly correlated with decline of MLS in HM, which may help to evaluate and monitor visual impairment in HM.

AB - PURPOSE. To investigate structural changes in the retinal outer layers and choroid using adaptive optics (AO) and optical coherence tomography (OCT) in eyes with myopia, and to correlate the changes with decreased macular light sensitivity (MLS). METHODS. This prospective study included 27 subjects with emmetropia and low myopia (EM/LM), 25 with moderate myopia (MM), and 25 with high myopia (HM). Microperimetry was used to quantify MLS in each subject, while AO and OCT images of fundus were analyzed to quantify cone density and regularity and thickness of outer retinal sublayers and choroid. Differences of MLS, cone distribution, and chorioretinal thicknesses were compared among the three groups, and the associations among photoreceptor morphological alterations, MLS, and other parameters were analyzed. RESULTS. In HM, the MLS, cone density and regularity, and thicknesses of the myoid and ellipsoid zone (MEZ), Henle fiber layer and outer nuclear layer, interdigitation zone and RPE/Bruch complex, and choroid were lower than in EM/LM. Decreased MLS was correlated with lower cone density and regularity, and thinner MEZ and choroid in the inner region, and with lower cone density, thinner MEZ and choroid, and longer axial length in the outer region. Multivariate regression showed that better MLS was correlated with thicker MEZ in the inner region and with higher cone density in the outer region. CONCLUSIONS. Altered cone distribution and outer retinal thickness, especially cone density and MEZ thickness, were significantly correlated with decline of MLS in HM, which may help to evaluate and monitor visual impairment in HM.

KW - Adaptive optics

KW - High myopia

KW - Macular retinal sensitivity

KW - Optical coherence tomography

KW - Photoreceptor degeneration

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