Photopolymerized hydrogel materials for drug delivery applications

Jennifer L. West, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

194 Scopus citations

Abstract

A novel photopolymerized hydrogel material has been developed for use as a drug delivery vehicle for bioactive materials. The hydrogel precursor consists of polyethylene glycol copolymerized with an α-hydroxy acid and with acrylate termini at each end. The precursor is water-soluble and non-toxic. The precursor polymerization conditions are very mild, and polymerization can be carried out in direct contact with cells and tissues. The degradation rate and permeability of the hydrogel can be altered by changing the composition of the precursors, allowing use of this class of materials for a variety of applications. In vitro release of proteins and oligonucleotides is reported.

Original languageEnglish (US)
Pages (from-to)139-147
Number of pages9
JournalReactive Polymers
Volume25
Issue number2-3
DOIs
StatePublished - Jun 1995

Keywords

  • Bioactive material
  • Drug delivery vehicle
  • Non-toxic precursor
  • Photopolymerized hydrogel
  • Water soluble

ASJC Scopus subject areas

  • Engineering(all)

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