Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin in the ocular histoplasmosis syndrome: One-year results of an uncontrolled, prospective case series

David A. Saperstein, Philip J Rosenfeld, Neil M. Bressler, Robert H. Rosa, Michel Sickenberg, Paul Sternberg, Thomas M. Aaberg, Thomas M. Aaberg, Troy A. Reaves

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Objective: To evaluate the safety and effect on visual acuity of photodynamic therapy with verteporfin (Visudyne, Novartis AG) in patients with subfoveal choroidal neovascularization (CNV) secondary to the ocular histoplasmosis syndrome (OHS). Design: Open-label, three-center, noncomparative prospective case series. Participants: OHS patients with subfoveal CNV lesions no larger than 5400 μm in greatest linear dimension (GLD) with classic or occult CNV extending under the geometric center of the foveal avascular zone and best-corrected visual acuity letter score of 73 to 34 (approximate Snellen equivalent 20/40-20/200). Methods: Twenty-six patients received verteporfin (6 mg/m2) infused IV over 10 minutes. Fifteen minutes after the start of infusion, a laser light at 689 nm delivered 50 J/cm2 at an intensity of 600 mW/cm2 over 83 seconds using a spot size with a diameter 1000 μm larger than the GLD of the lesion. At 3-month follow-up examinations, retreatment with the same regimen was applied if angiography showed fluorescein leakage. Safety assessments were also made. Main Outcome Measures: Visual function measurements were the changes from baseline in visual acuity and contrast sensitivity scores and the proportion of patients who, based on best-corrected visual acuity scores, (1) gained 7 or more letters, (2) lost 8 or more letters, and (3) lost 15 or more letters. Results: One patient was omitted from the study at the month 3 examination for not meeting the visual acuity eligibility requirements at baseline. By the month 12 examination, but excluding any retreatment at that visit, patients had received an average of 2.9 treatments of a maximum of 4 possible treatments. The month 12 median improvement from baseline in visual acuity of the remaining 25 patients was 7 letters, and median contrast sensitivity improved by 2 letters. Median visual acuity improvement was also 7 letters when three patients, who failed to meet all photographic eligibility requirements at baseline, were excluded. At the month 12 examination, 14 (56%) patients gained 7 or more letters of visual acuity from baseline, whereas 4 (16%) patients lost 8 or more letters, of which 2 (8%) lost 15 or more letters. No serious systemic or ocular adverse events were reported. Conclusions: Median visual acuity improved after verteporfin therapy for at least 1 year in a small uncontrolled prospective case series of patients with subfoveal CNV caused by OHS. Verteporfin therapy seemed to be safe and well tolerated in these patients. Two-year data from this study will provide important, additional information on the safety and effect of verteporfin therapy for the treatment of subfoveal CNV secondary to OHS.

Original languageEnglish
Pages (from-to)1499-1505
Number of pages7
JournalOphthalmology
Volume109
Issue number8
DOIs
StatePublished - Aug 26 2002
Externally publishedYes

Fingerprint

Histoplasmosis
Choroidal Neovascularization
Photochemotherapy
Visual Acuity
Contrast Sensitivity
Retreatment
Safety
verteporfin
Therapeutics
Fluorescein Angiography
Lasers

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin in the ocular histoplasmosis syndrome : One-year results of an uncontrolled, prospective case series. / Saperstein, David A.; Rosenfeld, Philip J; Bressler, Neil M.; Rosa, Robert H.; Sickenberg, Michel; Sternberg, Paul; Aaberg, Thomas M.; Aaberg, Thomas M.; Reaves, Troy A.

In: Ophthalmology, Vol. 109, No. 8, 26.08.2002, p. 1499-1505.

Research output: Contribution to journalArticle

Saperstein, David A. ; Rosenfeld, Philip J ; Bressler, Neil M. ; Rosa, Robert H. ; Sickenberg, Michel ; Sternberg, Paul ; Aaberg, Thomas M. ; Aaberg, Thomas M. ; Reaves, Troy A. / Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin in the ocular histoplasmosis syndrome : One-year results of an uncontrolled, prospective case series. In: Ophthalmology. 2002 ; Vol. 109, No. 8. pp. 1499-1505.
@article{a3084f5902044c24bbab4debe3f610b8,
title = "Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin in the ocular histoplasmosis syndrome: One-year results of an uncontrolled, prospective case series",
abstract = "Objective: To evaluate the safety and effect on visual acuity of photodynamic therapy with verteporfin (Visudyne, Novartis AG) in patients with subfoveal choroidal neovascularization (CNV) secondary to the ocular histoplasmosis syndrome (OHS). Design: Open-label, three-center, noncomparative prospective case series. Participants: OHS patients with subfoveal CNV lesions no larger than 5400 μm in greatest linear dimension (GLD) with classic or occult CNV extending under the geometric center of the foveal avascular zone and best-corrected visual acuity letter score of 73 to 34 (approximate Snellen equivalent 20/40-20/200). Methods: Twenty-six patients received verteporfin (6 mg/m2) infused IV over 10 minutes. Fifteen minutes after the start of infusion, a laser light at 689 nm delivered 50 J/cm2 at an intensity of 600 mW/cm2 over 83 seconds using a spot size with a diameter 1000 μm larger than the GLD of the lesion. At 3-month follow-up examinations, retreatment with the same regimen was applied if angiography showed fluorescein leakage. Safety assessments were also made. Main Outcome Measures: Visual function measurements were the changes from baseline in visual acuity and contrast sensitivity scores and the proportion of patients who, based on best-corrected visual acuity scores, (1) gained 7 or more letters, (2) lost 8 or more letters, and (3) lost 15 or more letters. Results: One patient was omitted from the study at the month 3 examination for not meeting the visual acuity eligibility requirements at baseline. By the month 12 examination, but excluding any retreatment at that visit, patients had received an average of 2.9 treatments of a maximum of 4 possible treatments. The month 12 median improvement from baseline in visual acuity of the remaining 25 patients was 7 letters, and median contrast sensitivity improved by 2 letters. Median visual acuity improvement was also 7 letters when three patients, who failed to meet all photographic eligibility requirements at baseline, were excluded. At the month 12 examination, 14 (56{\%}) patients gained 7 or more letters of visual acuity from baseline, whereas 4 (16{\%}) patients lost 8 or more letters, of which 2 (8{\%}) lost 15 or more letters. No serious systemic or ocular adverse events were reported. Conclusions: Median visual acuity improved after verteporfin therapy for at least 1 year in a small uncontrolled prospective case series of patients with subfoveal CNV caused by OHS. Verteporfin therapy seemed to be safe and well tolerated in these patients. Two-year data from this study will provide important, additional information on the safety and effect of verteporfin therapy for the treatment of subfoveal CNV secondary to OHS.",
author = "Saperstein, {David A.} and Rosenfeld, {Philip J} and Bressler, {Neil M.} and Rosa, {Robert H.} and Michel Sickenberg and Paul Sternberg and Aaberg, {Thomas M.} and Aaberg, {Thomas M.} and Reaves, {Troy A.}",
year = "2002",
month = "8",
day = "26",
doi = "10.1016/S0161-6420(02)01103-X",
language = "English",
volume = "109",
pages = "1499--1505",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin in the ocular histoplasmosis syndrome

T2 - One-year results of an uncontrolled, prospective case series

AU - Saperstein, David A.

AU - Rosenfeld, Philip J

AU - Bressler, Neil M.

AU - Rosa, Robert H.

AU - Sickenberg, Michel

AU - Sternberg, Paul

AU - Aaberg, Thomas M.

AU - Aaberg, Thomas M.

AU - Reaves, Troy A.

PY - 2002/8/26

Y1 - 2002/8/26

N2 - Objective: To evaluate the safety and effect on visual acuity of photodynamic therapy with verteporfin (Visudyne, Novartis AG) in patients with subfoveal choroidal neovascularization (CNV) secondary to the ocular histoplasmosis syndrome (OHS). Design: Open-label, three-center, noncomparative prospective case series. Participants: OHS patients with subfoveal CNV lesions no larger than 5400 μm in greatest linear dimension (GLD) with classic or occult CNV extending under the geometric center of the foveal avascular zone and best-corrected visual acuity letter score of 73 to 34 (approximate Snellen equivalent 20/40-20/200). Methods: Twenty-six patients received verteporfin (6 mg/m2) infused IV over 10 minutes. Fifteen minutes after the start of infusion, a laser light at 689 nm delivered 50 J/cm2 at an intensity of 600 mW/cm2 over 83 seconds using a spot size with a diameter 1000 μm larger than the GLD of the lesion. At 3-month follow-up examinations, retreatment with the same regimen was applied if angiography showed fluorescein leakage. Safety assessments were also made. Main Outcome Measures: Visual function measurements were the changes from baseline in visual acuity and contrast sensitivity scores and the proportion of patients who, based on best-corrected visual acuity scores, (1) gained 7 or more letters, (2) lost 8 or more letters, and (3) lost 15 or more letters. Results: One patient was omitted from the study at the month 3 examination for not meeting the visual acuity eligibility requirements at baseline. By the month 12 examination, but excluding any retreatment at that visit, patients had received an average of 2.9 treatments of a maximum of 4 possible treatments. The month 12 median improvement from baseline in visual acuity of the remaining 25 patients was 7 letters, and median contrast sensitivity improved by 2 letters. Median visual acuity improvement was also 7 letters when three patients, who failed to meet all photographic eligibility requirements at baseline, were excluded. At the month 12 examination, 14 (56%) patients gained 7 or more letters of visual acuity from baseline, whereas 4 (16%) patients lost 8 or more letters, of which 2 (8%) lost 15 or more letters. No serious systemic or ocular adverse events were reported. Conclusions: Median visual acuity improved after verteporfin therapy for at least 1 year in a small uncontrolled prospective case series of patients with subfoveal CNV caused by OHS. Verteporfin therapy seemed to be safe and well tolerated in these patients. Two-year data from this study will provide important, additional information on the safety and effect of verteporfin therapy for the treatment of subfoveal CNV secondary to OHS.

AB - Objective: To evaluate the safety and effect on visual acuity of photodynamic therapy with verteporfin (Visudyne, Novartis AG) in patients with subfoveal choroidal neovascularization (CNV) secondary to the ocular histoplasmosis syndrome (OHS). Design: Open-label, three-center, noncomparative prospective case series. Participants: OHS patients with subfoveal CNV lesions no larger than 5400 μm in greatest linear dimension (GLD) with classic or occult CNV extending under the geometric center of the foveal avascular zone and best-corrected visual acuity letter score of 73 to 34 (approximate Snellen equivalent 20/40-20/200). Methods: Twenty-six patients received verteporfin (6 mg/m2) infused IV over 10 minutes. Fifteen minutes after the start of infusion, a laser light at 689 nm delivered 50 J/cm2 at an intensity of 600 mW/cm2 over 83 seconds using a spot size with a diameter 1000 μm larger than the GLD of the lesion. At 3-month follow-up examinations, retreatment with the same regimen was applied if angiography showed fluorescein leakage. Safety assessments were also made. Main Outcome Measures: Visual function measurements were the changes from baseline in visual acuity and contrast sensitivity scores and the proportion of patients who, based on best-corrected visual acuity scores, (1) gained 7 or more letters, (2) lost 8 or more letters, and (3) lost 15 or more letters. Results: One patient was omitted from the study at the month 3 examination for not meeting the visual acuity eligibility requirements at baseline. By the month 12 examination, but excluding any retreatment at that visit, patients had received an average of 2.9 treatments of a maximum of 4 possible treatments. The month 12 median improvement from baseline in visual acuity of the remaining 25 patients was 7 letters, and median contrast sensitivity improved by 2 letters. Median visual acuity improvement was also 7 letters when three patients, who failed to meet all photographic eligibility requirements at baseline, were excluded. At the month 12 examination, 14 (56%) patients gained 7 or more letters of visual acuity from baseline, whereas 4 (16%) patients lost 8 or more letters, of which 2 (8%) lost 15 or more letters. No serious systemic or ocular adverse events were reported. Conclusions: Median visual acuity improved after verteporfin therapy for at least 1 year in a small uncontrolled prospective case series of patients with subfoveal CNV caused by OHS. Verteporfin therapy seemed to be safe and well tolerated in these patients. Two-year data from this study will provide important, additional information on the safety and effect of verteporfin therapy for the treatment of subfoveal CNV secondary to OHS.

UR - http://www.scopus.com/inward/record.url?scp=0036343021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036343021&partnerID=8YFLogxK

U2 - 10.1016/S0161-6420(02)01103-X

DO - 10.1016/S0161-6420(02)01103-X

M3 - Article

C2 - 12153802

AN - SCOPUS:0036343021

VL - 109

SP - 1499

EP - 1505

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 8

ER -