Photodynamic therapy in dermatology: A review

Sonal Choudhary, Keyvan Nouri, Mohamed L. Elsaie

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations

Abstract

Photodynamic therapy (PDT) is used for the prevention and treatment of non-melanoma skin cancer. Until recently, clinically approved indications have been restricted to actinic keratoses, nodular and superficial basal cell carcinoma, and, since 2006, Bowen disease. However, the range of indications has been expanding continuously. PDT is also used for the treatment of non-malignant conditions such as acne vulgaris and leishmaniasis, as well as for treating premature skin aging due to sun exposure. The production of reactive oxygen intermediates like singlet oxygen depends on the light dose applied as well as the concentration and localization of the photosensitizer in the diseased tissue. Either cytotoxic effects resulting in tumor destruction or immunomodulatory effects improving inflammatory skin conditions are induced. Treating superficial non-melanoma skin cancer, PDT has been shown to be highly efficient, despite the low level of invasiveness. The excellent cosmetic results after treatment are beneficial, too.

Original languageEnglish (US)
Pages (from-to)971-980
Number of pages10
JournalLasers in medical science
Volume24
Issue number6
DOIs
StatePublished - Nov 1 2009

Keywords

  • Actinic keratosis (AK)
  • Light emitting diode (LED)
  • Photodynamic therapy (PDT)
  • Porphyrins

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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