TY - JOUR
T1 - Photodynamic therapy in dermatology
T2 - A review
AU - Choudhary, Sonal
AU - Nouri, Keyvan
AU - Elsaie, Mohamed L.
PY - 2009/11/1
Y1 - 2009/11/1
N2 - Photodynamic therapy (PDT) is used for the prevention and treatment of non-melanoma skin cancer. Until recently, clinically approved indications have been restricted to actinic keratoses, nodular and superficial basal cell carcinoma, and, since 2006, Bowen disease. However, the range of indications has been expanding continuously. PDT is also used for the treatment of non-malignant conditions such as acne vulgaris and leishmaniasis, as well as for treating premature skin aging due to sun exposure. The production of reactive oxygen intermediates like singlet oxygen depends on the light dose applied as well as the concentration and localization of the photosensitizer in the diseased tissue. Either cytotoxic effects resulting in tumor destruction or immunomodulatory effects improving inflammatory skin conditions are induced. Treating superficial non-melanoma skin cancer, PDT has been shown to be highly efficient, despite the low level of invasiveness. The excellent cosmetic results after treatment are beneficial, too.
AB - Photodynamic therapy (PDT) is used for the prevention and treatment of non-melanoma skin cancer. Until recently, clinically approved indications have been restricted to actinic keratoses, nodular and superficial basal cell carcinoma, and, since 2006, Bowen disease. However, the range of indications has been expanding continuously. PDT is also used for the treatment of non-malignant conditions such as acne vulgaris and leishmaniasis, as well as for treating premature skin aging due to sun exposure. The production of reactive oxygen intermediates like singlet oxygen depends on the light dose applied as well as the concentration and localization of the photosensitizer in the diseased tissue. Either cytotoxic effects resulting in tumor destruction or immunomodulatory effects improving inflammatory skin conditions are induced. Treating superficial non-melanoma skin cancer, PDT has been shown to be highly efficient, despite the low level of invasiveness. The excellent cosmetic results after treatment are beneficial, too.
KW - Actinic keratosis (AK)
KW - Light emitting diode (LED)
KW - Photodynamic therapy (PDT)
KW - Porphyrins
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U2 - 10.1007/s10103-009-0716-x
DO - 10.1007/s10103-009-0716-x
M3 - Review article
C2 - 19653060
AN - SCOPUS:70350220893
VL - 24
SP - 971
EP - 980
JO - Lasers in Medical Science
JF - Lasers in Medical Science
SN - 0268-8921
IS - 6
ER -