Photodynamic Therapy for Infectious Keratitis

Diego Altamirano, Jaime Martinez, Katherine D. Leviste, Jean Marie Parel, Guillermo Amescua

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Purpose of Review: Due to the invasive nature of the keratoplasty and the shortage of available donor tissue around the world, alternative treatments are needed for the management of progressive infectious keratitis. Recent Findings: Infectious keratitis is a sight-threatening microbial infection. The prevalence of antimicrobial resistance in cases of infectious keratitis has increased the demand for fortified compounded antimicrobial drops. Even with proper medical management, severe cases of infectious keratitis can further evolve into corneal perforation, requiring surgical intervention in the form of keratoplasty to control the infectious process. In ophthalmology, photodynamic therapy (PDT) has been used for numerous applications. Summary: PDT with Rose Bengal as a photosensitizer combined with green light optical irradiation (RB-PDAT) is a novel treatment with dual purpose: to arrest the infection from progressing and strengthen the collagen of the cornea. RB-PDAT may be considered as an adjunct therapy in severe cases of infectious keratitis to minimize the need for a therapeutic keratoplasty.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalCurrent Ophthalmology Reports
Issue number4
StatePublished - Dec 2020


  • Cornea
  • Epithelial defect
  • Infectious keratitis
  • Ocular surface
  • Rose bengal photodynamic antimicrobial therapy

ASJC Scopus subject areas

  • Ophthalmology


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