TY - JOUR
T1 - Photodynamic therapy for actinic cheilitis
T2 - A systematic review
AU - Yazdani Abyaneh, Mohammad Ali
AU - Falto-Aizpurua, Leyre
AU - Griffith, Robert D.
AU - Nouri, Keyvan
PY - 2015/2/13
Y1 - 2015/2/13
N2 - BACKGROUND: Actinic cheilitis (AC) is a premalignant lesion of the lips that can progress to squamous cell carcinoma and metastasize. Actinic cheilitis is difficult to treat because surgical treatments have significant adverse effects whereas less invasive procedures have uncertain efficacy. Photodynamic therapy (PDT) may offer a noninvasive yet effective treatment option for AC. OBJECTIVE: To systematically review the safety and efficacy of PDT for AC. METHODS: The terms "photodynamic," "actinic," "solar," "cheilitis," and "cheilosis" were used in combinations to search the PubMed database. Studies were considered for inclusion based on eligibility criteria, and specific data were extracted from all studies. RESULTS: The authors identified 15 eligible case series encompassing a total of 242 treated subjects. Among studies that evaluated subjects for complete clinical response, 139 of 223 subjects (62%) showed complete response at final follow-ups ranging from 3 to 30 months. Among studies that evaluated subjects for histological outcome, 57 of 121 subjects (47%) demonstrated histological cure at final follow-ups ranging from 1.5 to 18 months. Cosmetic outcomes were good to excellent in the majority of subjects, and adverse events were well tolerated. CONCLUSION: Photodynamic therapy is safe and has the potential to clinically and histologically treat AC, with a need for future randomized controlled trials.
AB - BACKGROUND: Actinic cheilitis (AC) is a premalignant lesion of the lips that can progress to squamous cell carcinoma and metastasize. Actinic cheilitis is difficult to treat because surgical treatments have significant adverse effects whereas less invasive procedures have uncertain efficacy. Photodynamic therapy (PDT) may offer a noninvasive yet effective treatment option for AC. OBJECTIVE: To systematically review the safety and efficacy of PDT for AC. METHODS: The terms "photodynamic," "actinic," "solar," "cheilitis," and "cheilosis" were used in combinations to search the PubMed database. Studies were considered for inclusion based on eligibility criteria, and specific data were extracted from all studies. RESULTS: The authors identified 15 eligible case series encompassing a total of 242 treated subjects. Among studies that evaluated subjects for complete clinical response, 139 of 223 subjects (62%) showed complete response at final follow-ups ranging from 3 to 30 months. Among studies that evaluated subjects for histological outcome, 57 of 121 subjects (47%) demonstrated histological cure at final follow-ups ranging from 1.5 to 18 months. Cosmetic outcomes were good to excellent in the majority of subjects, and adverse events were well tolerated. CONCLUSION: Photodynamic therapy is safe and has the potential to clinically and histologically treat AC, with a need for future randomized controlled trials.
UR - http://www.scopus.com/inward/record.url?scp=84922675848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922675848&partnerID=8YFLogxK
U2 - 10.1097/DSS.0000000000000254
DO - 10.1097/DSS.0000000000000254
M3 - Article
C2 - 25627629
AN - SCOPUS:84922675848
VL - 41
SP - 189
EP - 198
JO - Dermatologic Surgery
JF - Dermatologic Surgery
SN - 1076-0512
IS - 2
ER -