Photodynamic therapy

Photodynamic therapy (PDT) refers to the therapeutic use of a locally concentrated photosensitizing agent and subsequent light irradiation to produce reactive oxygen intermediates, specifically singlet oxygen species. The accumulation of the light-induced singlet oxygen in the target tissue causes selective damage to biologically important structures. PDT has an extensive history of use in oncology and has recently gained popularity in the management of dermatologic conditions, both malignant and benign. PDT has quickly become an attractive option for the non-invasive treatment of a variety of dermatologic indications due to a low incidence of adverse events and excellent cosmetic outcomes, even when treating large and/or multiple lesions. This chapter will discuss the currently supported indications as well as any known contraindications to PDT use in dermatology. Procedural techniques and pre- and post-operative considerations will also be addressed along with prevention and management of complications associated with the use of PDT.