Abstract
We have developed in the rat a minimally invasive model of reproducible spinal cord injury initiated photochemically. With the exposed spinal column intact, 560 nm irradiation of the translucent dorsal surface induces excitation of the systemically injected dye, rose Bengal, in the spinal cord microvasculature. The resultant photochemical reaction leads to vascular stasis. Histopathological changes at 7 days include hemorrhagic necrosis of the central gray matter, edematous pale-staining white matter tracts and vascular congestion. At the level of cord irradiation (T8) the entire cord thickness is necrosed except for the periphery of the anterior funiculus. Voluntary motor function is consistently lost in the subacute phase of injury.
| Original language | English |
|---|---|
| Pages (from-to) | 296-300 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 367 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Mar 5 1986 |
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Keywords
- infarction
- microvascular stasis
- photochemical sensitization
- singlet oxygen
- spinal cord injury
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Photochemically induced spinal cord injury in the rat. / Watson, Brant D.; Prado, Ricardo; Dalton Dietrich, W.; Ginsberg, Myron; Green, Barth A.
In: Brain Research, Vol. 367, No. 1-2, 05.03.1986, p. 296-300.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Photochemically induced spinal cord injury in the rat
AU - Watson, Brant D.
AU - Prado, Ricardo
AU - Dalton Dietrich, W.
AU - Ginsberg, Myron
AU - Green, Barth A
PY - 1986/3/5
Y1 - 1986/3/5
N2 - We have developed in the rat a minimally invasive model of reproducible spinal cord injury initiated photochemically. With the exposed spinal column intact, 560 nm irradiation of the translucent dorsal surface induces excitation of the systemically injected dye, rose Bengal, in the spinal cord microvasculature. The resultant photochemical reaction leads to vascular stasis. Histopathological changes at 7 days include hemorrhagic necrosis of the central gray matter, edematous pale-staining white matter tracts and vascular congestion. At the level of cord irradiation (T8) the entire cord thickness is necrosed except for the periphery of the anterior funiculus. Voluntary motor function is consistently lost in the subacute phase of injury.
AB - We have developed in the rat a minimally invasive model of reproducible spinal cord injury initiated photochemically. With the exposed spinal column intact, 560 nm irradiation of the translucent dorsal surface induces excitation of the systemically injected dye, rose Bengal, in the spinal cord microvasculature. The resultant photochemical reaction leads to vascular stasis. Histopathological changes at 7 days include hemorrhagic necrosis of the central gray matter, edematous pale-staining white matter tracts and vascular congestion. At the level of cord irradiation (T8) the entire cord thickness is necrosed except for the periphery of the anterior funiculus. Voluntary motor function is consistently lost in the subacute phase of injury.
KW - infarction
KW - microvascular stasis
KW - photochemical sensitization
KW - singlet oxygen
KW - spinal cord injury
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U2 - 10.1016/0006-8993(86)91606-9
DO - 10.1016/0006-8993(86)91606-9
M3 - Article
VL - 367
SP - 296
EP - 300
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -