Photochemical surface modification method for fibrin free intraocular lens

Yuji Sato, Nobuhiro Sato, Kazushige Shimizu, Mikio Sasou, Jean Marie Parel, Masataka Murahara

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations

Abstract

The dot patterned hydrophilic and hydrophobic groups were photo-chemically substituted in minute pattern on the polymethylmethacrylate [PMMA] intraocular lens [IOL] by the Xe 2 excimer lamp and the ArF excimer laser; consequently, the IOL that is free from fibrin has been developed. PMMA has been used as an intraocular lens IOL because of its high transmittance in the visible region and superb mechanical modifiability. However, protein and fat are stuck onto the lens surface after a long-term insertion, where cells proliferate; which causes the surface to get opaque, namely after-cataract. Firstly, the IOL was irradiated with Xe 2 excimer lamp in the presence of perfluoropolyether [PFPE] to be hydrophobic. By the photochemical reaction, the CF 3 functional groups were substituted on the IOL surface. In order to substitute hydrophilic groups in matrix-form on the surface, the ArF laser light was then irradiated on the hydrophobic surface in the presence of water through the 50μm φ dot-patterned negative mask and the lens to project the reduced pattern. With this selective photochemical surface modification, the hydrophilic and hydrophobic groups were arrayed alternately on the sample surface. The modified IOL was soaked in fibrin [FIB] water solution, and the fibrin-sticking rate was measured by infrared spectroscopy [FT-IR]. The lower fibrin-sticking rate of the IOL surface was achieved by the hydrophobic and hydrophilic micro domain structures. Furthermore, it was confirmed that the fibrin-sticking rate decreased as the OH group interval was narrowed. The modified surface with the 20 μm φ domains with hydrophilic and hydrophobic was lowest in fibrin sticking.

Original languageEnglish (US)
Article number45
Pages (from-to)260-267
Number of pages8
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5688
DOIs
StatePublished - Jul 21 2005
EventOphtalmic Technologies XV - San Jose, CA, United States
Duration: Jan 22 2005Jan 25 2005

Keywords

  • After cataract
  • Fibrin free
  • Micro domain structure
  • PMMAIOL
  • Photochemical reaction

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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