Phosphorylated inositol compounds in β-cell stimulus-response coupling

Christopher J. Barker, Ingo B. Leibiger, Barbara Leibiger, Per Olof Berggren

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Pancreatic β-cell function is essential for the regulation of glucose homeostasis in humans, and its impairment leads to the development of type 2 diabetes. Inputs from glucose and cell surface receptors act together to initiate the β-cell stimulus-response coupling that ultimately leads to the release of insulin. Phosphorylated inositol compounds have recently emerged as key players at all levels of the stimulus-secretion coupling process. In this current review, we seek to highlight recent advances in β-cell phosphoinositide research by dividing our examination into two sections. The first involves the events that lead to insulin secretion. This includes both new roles for inositol polyphosphates, particularly inositol hexakisphosphate, and both conventional and 3-phosphorylated inositol lipids. In the second section, we deal with the more novel concept of the autocrine role of insulin. Here, released insulin initiates signal transduction cascades, principally through the activity of phosphatidylinositol 3-kinase. This new round of signal transduction has been established to activate key β-cell genes, particularly the insulin gene itself. More controversially, this insulin feedback has also been suggested to either terminate or enhance insulin secretion events.

Original languageEnglish
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume283
Issue number6 46-6
StatePublished - Dec 1 2002
Externally publishedYes

Fingerprint

Inositol
Insulin
Signal transduction
Signal Transduction
Genes
Phosphatidylinositol 3-Kinase
Glucose
Polyphosphates
Phytic Acid
Secretory Pathway
Cell Surface Receptors
Medical problems
Phosphatidylinositols
Type 2 Diabetes Mellitus
Homeostasis
Feedback
Lipids
Research

Keywords

  • Inositol lipids
  • Inositol polyphosphates
  • Insulin receptor
  • Insulin secretion
  • Pancreatic β-cell

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

Cite this

Barker, C. J., Leibiger, I. B., Leibiger, B., & Berggren, P. O. (2002). Phosphorylated inositol compounds in β-cell stimulus-response coupling. American Journal of Physiology - Endocrinology and Metabolism, 283(6 46-6).

Phosphorylated inositol compounds in β-cell stimulus-response coupling. / Barker, Christopher J.; Leibiger, Ingo B.; Leibiger, Barbara; Berggren, Per Olof.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 283, No. 6 46-6, 01.12.2002.

Research output: Contribution to journalArticle

Barker, Christopher J. ; Leibiger, Ingo B. ; Leibiger, Barbara ; Berggren, Per Olof. / Phosphorylated inositol compounds in β-cell stimulus-response coupling. In: American Journal of Physiology - Endocrinology and Metabolism. 2002 ; Vol. 283, No. 6 46-6.
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