Phosphorylated inositol compounds in β-cell stimulus-response coupling

Christopher J. Barker, Ingo B. Leibiger, Barbara Leibiger, Per Olof Berggren

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Pancreatic β-cell function is essential for the regulation of glucose homeostasis in humans, and its impairment leads to the development of type 2 diabetes. Inputs from glucose and cell surface receptors act together to initiate the β-cell stimulus-response coupling that ultimately leads to the release of insulin. Phosphorylated inositol compounds have recently emerged as key players at all levels of the stimulus-secretion coupling process. In this current review, we seek to highlight recent advances in β-cell phosphoinositide research by dividing our examination into two sections. The first involves the events that lead to insulin secretion. This includes both new roles for inositol polyphosphates, particularly inositol hexakisphosphate, and both conventional and 3-phosphorylated inositol lipids. In the second section, we deal with the more novel concept of the autocrine role of insulin. Here, released insulin initiates signal transduction cascades, principally through the activity of phosphatidylinositol 3-kinase. This new round of signal transduction has been established to activate key β-cell genes, particularly the insulin gene itself. More controversially, this insulin feedback has also been suggested to either terminate or enhance insulin secretion events.

Original languageEnglish (US)
Pages (from-to)E1113-E1122
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume283
Issue number6 46-6
DOIs
StatePublished - Dec 1 2002

Keywords

  • Inositol lipids
  • Inositol polyphosphates
  • Insulin receptor
  • Insulin secretion
  • Pancreatic β-cell

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

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