Phosphocitrate prevents disease progression in murine progressive ankylosis

Hollis E. Krug, Maren L. Mahowald, Paul B. Halverson, John D. Sallis, Herman S Cheung

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective. Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression. Methods. Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle. Results. Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC-treated and the saline-treated mice. Conclusion. PC appears to inhibit disease progression in murine progressive ankylosis.

Original languageEnglish
Pages (from-to)1603-1611
Number of pages9
JournalArthritis and Rheumatism
Volume36
Issue number11
StatePublished - Nov 1 1993
Externally publishedYes

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Ankylosis
Disease Progression
Joint Diseases
phosphocitrate
Weights and Measures

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Krug, H. E., Mahowald, M. L., Halverson, P. B., Sallis, J. D., & Cheung, H. S. (1993). Phosphocitrate prevents disease progression in murine progressive ankylosis. Arthritis and Rheumatism, 36(11), 1603-1611.

Phosphocitrate prevents disease progression in murine progressive ankylosis. / Krug, Hollis E.; Mahowald, Maren L.; Halverson, Paul B.; Sallis, John D.; Cheung, Herman S.

In: Arthritis and Rheumatism, Vol. 36, No. 11, 01.11.1993, p. 1603-1611.

Research output: Contribution to journalArticle

Krug, HE, Mahowald, ML, Halverson, PB, Sallis, JD & Cheung, HS 1993, 'Phosphocitrate prevents disease progression in murine progressive ankylosis', Arthritis and Rheumatism, vol. 36, no. 11, pp. 1603-1611.
Krug HE, Mahowald ML, Halverson PB, Sallis JD, Cheung HS. Phosphocitrate prevents disease progression in murine progressive ankylosis. Arthritis and Rheumatism. 1993 Nov 1;36(11):1603-1611.
Krug, Hollis E. ; Mahowald, Maren L. ; Halverson, Paul B. ; Sallis, John D. ; Cheung, Herman S. / Phosphocitrate prevents disease progression in murine progressive ankylosis. In: Arthritis and Rheumatism. 1993 ; Vol. 36, No. 11. pp. 1603-1611.
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