Phosphocitrate as a potential therapeutic strategy for crystal deposition disease.

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

The deposition of basic calcium phosphate and calcium pyrophosphate dihydrate crystals in articular tissues is probably an under-recognized event. Clinical observations indicate that exaggerated and uniquely distributed cartilage degeneration is associated with these deposits. Measurements of putative markers of cartilage breakdown suggest that these crystals magnify the degenerative process. In vitro studies reveal two potential mechanisms by which crystals cause degeneration. These involve the stimulation of mitogenesis in synovial fibroblasts and the secretion of metalloproteinases by cells that phagocytose these crystals. Approaches that may ameliorate the degenerative process may ensue from new information about how crystals form and how they exert their biologic effects.

Original languageEnglish (US)
Pages (from-to)24-28
Number of pages5
JournalCurrent rheumatology reports
Volume3
Issue number1
DOIs
StatePublished - Feb 2001
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology

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