Phosphatidylserine-containing liposomes promote maximal survival of retinal neurons after ischemic injury

Galina Dvoriantchikova, Christian Agudelo, Eleut Hernandez, Valery I. Shestopalov, Dmitry Ivanov

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

We investigated the systemic effect of liposomes bearing apoptotic signals on the level of inflammation and neuronal death induced by ischemia-reperfusion (IR). Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylserine liposome treatment was the most efficient and correlated with significantly reduced neuronal death in the retina 7 days after reperfusion. The results of our study indicate that therapeutic strategy based on mimicking a systemic increase in apoptotic signaling can significantly reduce central nervous system damage induced by IR and improve neurologic outcome.

Original languageEnglish (US)
Pages (from-to)1755-1759
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume29
Issue number11
DOIs
StatePublished - 2009

Keywords

  • Apoptosis
  • Inflammation
  • Ischemia
  • Liposomes
  • Phosphatidylserine
  • Retinal pathology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

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