Phenotypic associations of tau and ApoE in Parkinson's disease

Spiridon Papapetropoulos, Matthew J. Farrer, Jeremy T. Stone, Nicole M. Milkovic, Owen A. Ross, Linda Calvo, Donald McQuorquodale, Deborah C. Mash

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Overlaps in clinical, pathological and molecular features of Parkinson's disease (PD), dementing and motor tauopathies have prompted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. To explore possible phenotypic implications, we studied common tau and ApoE gene polymorphisms, associated with Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and PD, in a clinically and pathologically characterized cohort of PD patients and aged control subjects. Our results reveal a novel association between PD-related hallucinations and H1H1 genotype. We also report an association between PDD and the presence of the ApoE ε4 allele. Better determination of subsets of PD patients based upon the presence of specific phenotypic features may improve the accuracy of association studies.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalNeuroscience Letters
Volume414
Issue number2
DOIs
StatePublished - Mar 6 2007

Keywords

  • ApoE
  • Association study
  • Dementia
  • Hallucinations
  • Phenotype
  • Post-mortem
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)

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    Papapetropoulos, S., Farrer, M. J., Stone, J. T., Milkovic, N. M., Ross, O. A., Calvo, L., McQuorquodale, D., & Mash, D. C. (2007). Phenotypic associations of tau and ApoE in Parkinson's disease. Neuroscience Letters, 414(2), 141-144. https://doi.org/10.1016/j.neulet.2006.12.008