Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes

Keith R. Berend, Jae U. Jung, Terence J. Boyle, J. Michael DiMaio, Salvatore A. Mungal, Ronald Charles Desrosiers, H. Kim Lyerly

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

Original languageEnglish (US)
Pages (from-to)6317-6321
Number of pages5
JournalJournal of Virology
Volume67
Issue number10
StatePublished - Oct 1993
Externally publishedYes

Fingerprint

Saimiriine herpesvirus 2
Saimiriine Herpesvirus 2
Herpesviridae Infections
cytotoxic T-lymphocytes
Cytotoxic T-Lymphocytes
infection
antigens
Antigens
T-lymphocytes
T-Lymphocytes
Phenotype
phenotype

ASJC Scopus subject areas

  • Immunology

Cite this

Berend, K. R., Jung, J. U., Boyle, T. J., DiMaio, J. M., Mungal, S. A., Desrosiers, R. C., & Lyerly, H. K. (1993). Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. Journal of Virology, 67(10), 6317-6321.

Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. / Berend, Keith R.; Jung, Jae U.; Boyle, Terence J.; DiMaio, J. Michael; Mungal, Salvatore A.; Desrosiers, Ronald Charles; Lyerly, H. Kim.

In: Journal of Virology, Vol. 67, No. 10, 10.1993, p. 6317-6321.

Research output: Contribution to journalArticle

Berend, KR, Jung, JU, Boyle, TJ, DiMaio, JM, Mungal, SA, Desrosiers, RC & Lyerly, HK 1993, 'Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes', Journal of Virology, vol. 67, no. 10, pp. 6317-6321.
Berend, Keith R. ; Jung, Jae U. ; Boyle, Terence J. ; DiMaio, J. Michael ; Mungal, Salvatore A. ; Desrosiers, Ronald Charles ; Lyerly, H. Kim. / Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. In: Journal of Virology. 1993 ; Vol. 67, No. 10. pp. 6317-6321.
@article{a2faeb64f0754345a5cfcd899d65eb4d,
title = "Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes",
abstract = "Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.",
author = "Berend, {Keith R.} and Jung, {Jae U.} and Boyle, {Terence J.} and DiMaio, {J. Michael} and Mungal, {Salvatore A.} and Desrosiers, {Ronald Charles} and Lyerly, {H. Kim}",
year = "1993",
month = "10",
language = "English (US)",
volume = "67",
pages = "6317--6321",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "10",

}

TY - JOUR

T1 - Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes

AU - Berend, Keith R.

AU - Jung, Jae U.

AU - Boyle, Terence J.

AU - DiMaio, J. Michael

AU - Mungal, Salvatore A.

AU - Desrosiers, Ronald Charles

AU - Lyerly, H. Kim

PY - 1993/10

Y1 - 1993/10

N2 - Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

AB - Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

UR - http://www.scopus.com/inward/record.url?scp=0027239551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027239551&partnerID=8YFLogxK

M3 - Article

C2 - 8396687

AN - SCOPUS:0027239551

VL - 67

SP - 6317

EP - 6321

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 10

ER -