Phase I/pilot study of SU5416 (semaxinib) in combination with irinotecan/bolus 5-FU/LV (IFL) in patients with metastatic colorectal cancer

Albert Craig Lockhart, Gillian F. Cropp, Jordan D. Berlin, Edwin Donnelly, Robert D. Schumaker, Larry J. Schaaf, Kenneth R. Hande, Arthur C. Fleischer, Alison L. Hannah, Mace L. Rothenberg

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

OBJECTIVES: Determine the toxicity, tolerability, and pharmacokinetics of SU5416, a vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor, coadministered with bolus 5-fluorouracil (5-FU), leucovorin, and irinotecan (IFL) in untreated patients with metastatic colorectal cancer. METHODS: SU5416 (85 or 145 mg/m) was administered twice weekly throughout a 6-week period along with standard IFL (4 weeks on/2 weeks off). Plasma samples were assayed for SU5416, irinotecan, and SN-38 by reverse-phase HPLC. Contrast enhanced, color Doppler sonography was performed on patients at the MTD to identify changes in tumor perfusion. RESULTS: Eleven patients received treatment with SU5416 85 mg/m (n = 5) or 145 mg/m (n = 6). At 85 mg/m, no DLTs were observed. At 145 mg/m, grade 3 diarrhea and vomiting were observed during cycle 1; other grade 3 toxicities included fatigue, nausea, anorexia, anemia, pain, urinary retention, and hypertension. The pharmacokinetics of irinotecan and SN-38 were not altered by coadministration of SU5416. SU5416 pharmacokinetics were not altered by IFL. Contrast-enhanced, color Doppler sonography was performed on 2 patients and demonstrated reduced tumor perfusion after treatment in a patient who responded to treatment and increased perfusion in a patient who developed progressive disease. Three patients (27%) had confirmed partial responses, 2 patients (18%) had unconfirmed partial responses, and 4 patients (36%) had stable disease. CONCLUSIONS: Twice weekly SU5416 can be administered with bolus IFL without unexpected toxicities or altering the pharmacokinetic behavior of the administered drugs. Changes in tumor blood perfusion can be detected by contrast-enhanced, color Doppler sonography. The further development of SU5416 was halted before this study was completed.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume29
Issue number2
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

Keywords

  • 5-fluorouracil
  • Angiogenesis
  • Irinotecan
  • Phase I clinical trial
  • SU5416
  • Semaxinib
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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