Phase ii trial of mitoxantrone in advanced gastric cancer

Alec Goldenberg, David Kelsen, Pasquale Benedetto

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A Phase II trial of mitoxantrone was performed in patients with advanced adenocarcinoma of the stomach. All patients had measurable or evaluable disease, and none had received prior chemotherapy. Mitoxantrone was administered intravenously at a dose of 14 mg/m2 every 3 weeks. The major toxicity seen was myelosuppression. The drug was, in general, well tolerated. No major objective responses were seen. We conclude that mitoxantrone has < 20% activity in this patient population. No further studies are planned.

Original languageEnglish (US)
Pages (from-to)273-275
Number of pages3
JournalOncology (Switzerland)
Volume45
Issue number4
DOIs
StatePublished - Jan 1 1988

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Keywords

  • Gastric cancer
  • Mitoxantrone

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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