Phase I trial of pentosan polysulfate

Sandra M. Swain, Bernard Parker, Anton Wellstein, Marc E. Lippman, Caryn Steakley, Robert DeLap

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Pentosan polysulfate is a semisynthetic pentasaccharide heparinoid derived from beechwood shavings. A total of nineteen patients with various adult solid tumors were treated with three dose levels (15, 22.5, and 30 mg/m2/dose) of subcutaneous pentosan polysulfate every 6 hours. The dose limiting toxicities were thrombocytopenia and elevated transaminases at the dose of 30 mg/m2 every 6 hours. The recommended starting dose for phase II trials is 22.5 mg/m2 given every 6 hours. There was an increase in anticoagulant activity as measured by activated partial thromboplastin time (aPTT) at the dose of 22.5 mg/m2 every 6 hours in most patients. There were no objective responses and three patients had stable disease lasting 16, 19 and 76 weeks.

Original languageEnglish (US)
Pages (from-to)55-62
Number of pages8
JournalInvestigational New Drugs: An Interdisciplinary Journal for Clinicians and Scientists
Volume13
Issue number1
DOIs
StatePublished - Mar 1995

Keywords

  • Adult solid tumors
  • Pentosan polysulfate
  • Phase I trial

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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    Swain, S. M., Parker, B., Wellstein, A., Lippman, M. E., Steakley, C., & DeLap, R. (1995). Phase I trial of pentosan polysulfate. Investigational New Drugs: An Interdisciplinary Journal for Clinicians and Scientists, 13(1), 55-62. https://doi.org/10.1007/BF02614221