Phase I clinical evaluation of oral and intravenous 4-demethoxydaunorubicin

John J. Kavanagh, Katherine Y. Yeung, Niramol Savaraj, Irwin H. Krakoff

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Thirteen patients were treated with both the oral and intravenous preparations of 4-demethoxydaunorubicin (DMDR). The drug was well tolerated in both forms. Neutropenia was the dose-limiting side-effect. Approximately 30% of the compound was absorbed when given orally. The maximum tolerated dose was 12.5 mg/m2 intravenously or 50 mg/m2 (10 mg/m2 q d × 5) orally, given every 21-28 days.

Original languageEnglish (US)
Pages (from-to)1187-1189
Number of pages3
JournalEuropean Journal of Cancer and Clinical Oncology
Issue number10
StatePublished - Oct 1985
Externally publishedYes

ASJC Scopus subject areas

  • Oncology


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