Phase angle as bioelectrical marker to identify elderly patients at risk of sarcopenia

Claudia Basile, David Della-Morte, Francesco Cacciatore, Gaetano Gargiulo, Gianluigi Galizia, Mario Roselli, Francesco Curcio, Domenico Bonaduce, Pasquale Abete

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Several markers have been associated with sarcopenia in the elderly, including bioelectrical indices. Phase angle (PhA) is an impedance parameter and it has been suggested as an indicator of cellular death. Thus, the relationship between PhA and muscle mass and strength was investigated in 207 consecutively elderly participants (mean age 76.2 ± 6.7. years) admitted for multidimensional geriatric evaluation. Muscle strength by grip strength using a hand-held dynamometer and muscle mass was measured by bioimpedentiometer. PhA was calculated directly with its arctangent (resistance. /. reactance. ×. 180°. /. π). Linear relationship among muscular mass and strength and with clinical and biochemical parameters, including PhA at uni- and multivariate analysis were performed. Linear regression analysis demonstrated that lower level of PhA is associated with reduction in grip strength (y = 3.16. +. 0.08x; r = 0.49; p. <. 0.001), and even more, with muscle mass (y = 3.04. +. 0.25x; r = 0.60; p. <. 0001). Multivariate analysis confirms these relationships (grip strength β = 0.245, p = 0.031; muscular mass β = 0.623, p. <. 0.01). Thus, PhA is inversely related to muscle mass and strength in elderly subjects and it may be considered a good bioelectrical marker to identify elderly patients at risk of sarcopenia.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalExperimental Gerontology
StatePublished - Oct 2014
Externally publishedYes


  • Angle phase
  • Bioelectrical impedance
  • Elderly
  • Sarcopenia

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology


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