Pharmacotherapy of large B-cell lymphoma

Maricer P. Escalón, Izidore S. Lossos

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Background: Constituting approximately 30% of lymphoid malignancies, diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma in adults worldwide. The clinical and biologic heterogeneity that exists in DLBCL suggests that this entity might actually be comprised of several distinct neoplasms that could require different therapeutic approaches. DLBCL was considered incurable until combination chemotherapy became available. Objective: Current treatment strategies for the treatment of untreated and relapsed advanced-stage DLBCL are reviewed; novel treatments for DLBCL are discussed. Methods: Relevant literature was identified using the PubMed search engine and by reviewing abstracts from major conference proceedings. Results/conclusion: Recently, novel therapeutic strategies, including the incorporation of immunotherapy to combination chemotherapy, have improved outcome for patients with DLBCL with cure rates exceeding 50%, especially in younger patients.

Original languageEnglish (US)
Pages (from-to)2247-2258
Number of pages12
JournalExpert Opinion on Pharmacotherapy
Volume9
Issue number13
DOIs
StatePublished - Sep 1 2008

Keywords

  • Ibritumomab tiuxetan
  • Lenalidomide
  • Lymphoma
  • Rituximab
  • Tositumomab

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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