Pharmacology of allergen-induced early and late airway responses and antigen-induced airway hyperresponsiveness in allergic sheep

W. M. Abraham

Research output: Contribution to journalArticle

19 Scopus citations


The pharmacology of antigen-induced early and late phase airway responses and the associated antigen-induced airway hyperresponsiveness was studied in allergic sheep. Data from studies with anti-allergic agents and specific receptor antagonists, especially leukotriene antagonists and antagonists of platelet activating factor (PAF), have led to the hypothesis that allergen-induced late responses in allergic sheep are linked to a heightened metabolism of arachidonic acid via the 5-lipoxygenase pathway. This increases leukotriene production during the acute allergic reaction, which results in a more prolonged acute bronchoconstriction and subsequently a more severe airway inflammation. These recruited inflammatory cells can then release mediators and other cell products which contribute to the late response and airway hyperresponsiveness.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalPulmonary Pharmacology
Issue number1
StatePublished - 1989


ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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