Pharmacological profile of MDL 26,024GO: A novel antiasthmatic agent

L. Baugh; W. Abraham; E. Matthews; P. Lahr

doi:10.1007/BF01972843

Pharmacological profile of MDL 26,024GO: A novel antiasthmatic agent

L. Baugh, W. Abraham, E. Matthews, P. Lahr

Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

MDL 26,024GO was shown to be an orally absorbed mediator release inhibitor in the rat PCA and PPA tests. In addition, the compound was shown to both elicit and inhibit elicitation of the Bezold-Jarisch reflex in the dog. MDL 26,024GO also significantly reduced Ascaris-induced changes in pulmonary mechanics in cynomolgus monkeys. The compound inhibited both early and late phase antigen induced-changes in Ascaris-sensitive sheep, as well as the increased airway hyperreactivity which normally follows antigen challenge. These results suggest the compound may have therapeutic potential in the treatment of asthma.

Original language	English (US)
Pages (from-to)	431-434
Number of pages	4
Journal	Agents and Actions
Volume	27
Issue number	3-4
DOIs	https://doi.org/10.1007/BF01972843
State	Published - Jun 1 1989

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

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abstract = "MDL 26,024GO was shown to be an orally absorbed mediator release inhibitor in the rat PCA and PPA tests. In addition, the compound was shown to both elicit and inhibit elicitation of the Bezold-Jarisch reflex in the dog. MDL 26,024GO also significantly reduced Ascaris-induced changes in pulmonary mechanics in cynomolgus monkeys. The compound inhibited both early and late phase antigen induced-changes in Ascaris-sensitive sheep, as well as the increased airway hyperreactivity which normally follows antigen challenge. These results suggest the compound may have therapeutic potential in the treatment of asthma.",

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AU - Abraham, W.

AU - Matthews, E.

AU - Lahr, P.

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AB - MDL 26,024GO was shown to be an orally absorbed mediator release inhibitor in the rat PCA and PPA tests. In addition, the compound was shown to both elicit and inhibit elicitation of the Bezold-Jarisch reflex in the dog. MDL 26,024GO also significantly reduced Ascaris-induced changes in pulmonary mechanics in cynomolgus monkeys. The compound inhibited both early and late phase antigen induced-changes in Ascaris-sensitive sheep, as well as the increased airway hyperreactivity which normally follows antigen challenge. These results suggest the compound may have therapeutic potential in the treatment of asthma.

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