Pharmacological dissociation of the b-wave and pattern electroretinogram

V. Porciatti, P. Bagnoli, R. Alesci, G. Fontanesi

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Electroretinographic responses to modulation of either luminance (focal ERG) or spatial contrast (pattern ERG) were recorded from the pigeon eye before and after intravitreal injection of glutamate analogues DLα amino adipic acid (DLα AA) and 2-amino-4 phosphonobutyric acid (APB). Both toxins reversibly abolished the b-wave. The pattern ERG was still present, however, when the b-wave had been abolished by the toxins. This result demonstrates that the b-wave and the pattern ERG can be pharmacologically dissociated and suggests the possibility that in pigeons the b-wave and pattern ERG reflect the activity of different generators.

Original languageEnglish (US)
Pages (from-to)377-383
Number of pages7
JournalDocumenta Ophthalmologica
Volume65
Issue number3
DOIs
StatePublished - Mar 1 1987
Externally publishedYes

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Keywords

  • APB
  • contrast modulation
  • DLα AA
  • luminance variation
  • pigeon retina

ASJC Scopus subject areas

  • Ophthalmology

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