Pharmacological approaches to the management of cognitive dysfunction in schizophrenia

Philip D. Harvey, Margaret M. McClure

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Cognitive dysfunction is a core feature of schizophrenia as deficits that are present in the majority of patients with schizophrenia frequently precede the onset of other symptoms and persist even after other symptoms have been effectively treated. The use of atypical antipsychotics has produced some small improvements, although the need for adjunctive treatment specifically targeting cognitive dysfunction is gaining widespread acceptance. Animal models and some small clinical trials have yielded results that are promising but not definitive. Psychosocial interventions have also met with some success in ameliorating some cognitive limitations. The mixed results of pharmacological interventions are most likely to be as a result of a combination of methodological flaws of many studies, poor outcome measures, dose administration effects and problems with the agents themselves.

Original languageEnglish (US)
Pages (from-to)1465-1473
Number of pages9
Issue number11
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)


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