Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure

Ivan Jozic, Andrew P. Sawaya, Irena Pastar, Cheyanne R. Head, Lulu L. Wong, George D. Glinos, Tongyu Cao Wikramanayake, Harold Brem, Robert S. Kirsner, Marjana Tomic-Canic

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Compartmentalization of signaling events at caveolae is crucial during wound healing. Jozic and colleagues show that human non-healing chronic wounds exhibit elevated levels of Caveolin-1, which inhibits keratinocyte migration by sequestering EGFR while promoting glucocorticoid signaling. They further demonstrate that disruption of caveolae accelerates keratinocyte migration and wound closure.

Original languageEnglish (US)
Pages (from-to)1992-2004
Number of pages13
JournalMolecular Therapy
Volume27
Issue number11
DOIs
StatePublished - Nov 6 2019

Keywords

  • Caveolin-1
  • chronic wounds
  • diabetic foot ulcers
  • skin re-epithelialization
  • wound healing

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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