Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure

Ivan Jozic, Andrew P. Sawaya, Irena Pastar, Cheyanne R. Head, Lulu L. Wong, George D. Glinos, Tongyu Wikramanayake, Harold Brem, Robert Kirsner, Marjana Tomic-Canic

Research output: Contribution to journalArticle

3 Scopus citations


Compartmentalization of signaling events at caveolae is crucial during wound healing. Jozic and colleagues show that human non-healing chronic wounds exhibit elevated levels of Caveolin-1, which inhibits keratinocyte migration by sequestering EGFR while promoting glucocorticoid signaling. They further demonstrate that disruption of caveolae accelerates keratinocyte migration and wound closure.

Original languageEnglish (US)
JournalMolecular Therapy
StateAccepted/In press - Jan 1 2019



  • Caveolin-1
  • chronic wounds
  • diabetic foot ulcers
  • skin re-epithelialization
  • wound healing

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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