Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure

Ivan Jozic, Andrew P. Sawaya, Irena Pastar, Cheyanne R. Head, Lulu L. Wong, George D. Glinos, Tongyu Wikramanayake, Harold Brem, Robert Kirsner, Marjana Tomic-Canic

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Compartmentalization of signaling events at caveolae is crucial during wound healing. Jozic and colleagues show that human non-healing chronic wounds exhibit elevated levels of Caveolin-1, which inhibits keratinocyte migration by sequestering EGFR while promoting glucocorticoid signaling. They further demonstrate that disruption of caveolae accelerates keratinocyte migration and wound closure.

Original languageEnglish (US)
JournalMolecular Therapy
DOIs
StateAccepted/In press - Jan 1 2019

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Keywords

  • Caveolin-1
  • chronic wounds
  • diabetic foot ulcers
  • skin re-epithelialization
  • wound healing

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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