Pharmacologic treatment of knee osteoarthritis in athletic women.

Roy D Altman, Peter J. Fowler

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

There is a greater incidence of anterior cruciate ligament tears due to noncontact sports injuries in women compared with men. Anterior cruciate ligament tears are associated with accelerated development of knee osteoarthritis (OA), which is also more prevalent in women than in men. This article considers therapeutic modalities that are best suited for athletic women with knee OA. Clinical data on the safety and efficacy of pharmacotherapies for knee OA, including acetaminophen, oral nonsteroidal anti-inflammatory drugs (NSAIDs), and topical NSAIDs, are discussed, with attention paid to special considerations for women who participate in athletic activity. Adverse events associated with the use of acetaminophen and oral NSAIDs place potential limits on the dose and duration of therapy and may be of greater concern in female athletes than in other patient groups. Topical NSAIDs, which effect relief through the same mechanism of action as oral NSAIDs, produce dramatically lower systemic NSAID exposure compared with oral NSAIDs and are associated with a lower incidence of systemic adverse events. These findings, along with additional future studies, may have particular relevance to the choice of the most effective treatment options for athletic women with OA of the knee.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalPhysician and Sportsmedicine
Volume39
Issue number3
StatePublished - Sep 2011
Externally publishedYes

Fingerprint

Knee Osteoarthritis
Sports
Anti-Inflammatory Agents
Pharmaceutical Preparations
Acetaminophen
Therapeutics
Athletic Injuries
Incidence
Athletes
Safety
Drug Therapy

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Pharmacologic treatment of knee osteoarthritis in athletic women. / Altman, Roy D; Fowler, Peter J.

In: Physician and Sportsmedicine, Vol. 39, No. 3, 09.2011, p. 39-44.

Research output: Contribution to journalArticle

Altman, RD & Fowler, PJ 2011, 'Pharmacologic treatment of knee osteoarthritis in athletic women.', Physician and Sportsmedicine, vol. 39, no. 3, pp. 39-44.
Altman, Roy D ; Fowler, Peter J. / Pharmacologic treatment of knee osteoarthritis in athletic women. In: Physician and Sportsmedicine. 2011 ; Vol. 39, No. 3. pp. 39-44.
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