Pharmacologic pupillary modulation in the perioperative period

Eduardo Alfonso, Mark B. Abelson, Lisa M. Smith

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The perioperative management of the pupil is essential to the success of anterior segment surgery. A new dilating regimen was tested in 65 cases of cataract extraction and intraocular lens implantation. The α-adrenergic agonist, phenylephrine 2.5%, was used after pretreatment with the adrenergic β-blocker, timolol 0.5%. This treatment successfully dilated the pupil in all but three cases, was maintained by intraoperative epinephrine infusion, and was readily reversed with intraocular acetylcholine. We conclude that this pharmacologic regimen provided a successful and easily reversible mydriasis during surgery.

Original languageEnglish (US)
Pages (from-to)78-80
Number of pages3
JournalJournal of cataract and refractive surgery
Issue number1
StatePublished - 1988
Externally publishedYes


  • acetylcholine
  • dilation
  • epinephrine
  • extracapsular cataract extraction
  • intraocular lens
  • phenylephrine
  • timolol

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology
  • Sensory Systems


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