Pharmacokinetics of nelfinavir and efavirenz in antiretroviral-naïve, human immunodeficiency virus-infected subjects when administered alone or in combination with nucleoside analog reverse transcriptase inhibitors

Patrick F. Smith, Gregory K. Robbins, Robert W. Shafer, Hulin Wu, Song Yu, Martin S. Hirsch, Thomas C. Merigan, Jeong Gun Park, Alan Forrest, Margaret A Fischl, Gene D. Morse

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Pharmacokinetic studies were conducted with human immunodeficiency virus-infected patients receiving efavirenz, nelfinavir, or both agents at weeks 4 and 32. Reductions of 25% and 45% were observed in the mean nelfinavir area under the concentration-time curve and minimum concentration of the drug in serum, and there was a 31% more rapid half-life for patients receiving both drugs compared to patients receiving nelfinavir alone. There were no significant differences in efavirenz pharmacokinetics.

Original languageEnglish
Pages (from-to)3558-3561
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number8
DOIs
StatePublished - Aug 1 2005

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efavirenz
Nelfinavir
Reverse Transcriptase Inhibitors
Nucleosides
Pharmacokinetics
HIV
Pharmaceutical Preparations
Half-Life
Serum

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Pharmacokinetics of nelfinavir and efavirenz in antiretroviral-naïve, human immunodeficiency virus-infected subjects when administered alone or in combination with nucleoside analog reverse transcriptase inhibitors. / Smith, Patrick F.; Robbins, Gregory K.; Shafer, Robert W.; Wu, Hulin; Yu, Song; Hirsch, Martin S.; Merigan, Thomas C.; Park, Jeong Gun; Forrest, Alan; Fischl, Margaret A; Morse, Gene D.

In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 8, 01.08.2005, p. 3558-3561.

Research output: Contribution to journalArticle

Smith, Patrick F. ; Robbins, Gregory K. ; Shafer, Robert W. ; Wu, Hulin ; Yu, Song ; Hirsch, Martin S. ; Merigan, Thomas C. ; Park, Jeong Gun ; Forrest, Alan ; Fischl, Margaret A ; Morse, Gene D. / Pharmacokinetics of nelfinavir and efavirenz in antiretroviral-naïve, human immunodeficiency virus-infected subjects when administered alone or in combination with nucleoside analog reverse transcriptase inhibitors. In: Antimicrobial Agents and Chemotherapy. 2005 ; Vol. 49, No. 8. pp. 3558-3561.
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