Pharmacokinetics of intravitreal antibiotics in endophthalmitis

Medikonda Radhika, Kopal Mithal, Abhishek Bawdekar, Vivek Dave, Animesh Jindal, Nidhi Relhan, Thomas A Albini, Avinash Pathengay, Harry W Flynn

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Intravitreal antibiotics are the mainstay of treatment in the management of infectious endophthalmitis. Basic knowledge of the commonly used intravitreal antibiotics, which includes their pharmacokinetics, half-life, duration of action and clearance, is essential for elimination of intraocular infection without any iatrogenic adverse effect to the ocular tissue. Various drugs have been studied over the past century to achieve this goal. We performed a comprehensive review of the antibiotics which have been used for intravitreal route and the pharmacokinetic factors influencing the drug delivery and safety profile of these antibiotics. Using online resources like PubMed and Google Scholar, articles were reviewed. The articles were confined to the English language only. We present a broad overview of pharmacokinetic concepts fundamental for use of intravitreal antibiotics in endophthalmitis along with a tabulated compendium of the intravitreal antibiotics using available literature. Recent advances for increasing bioavailability of antibiotics to the posterior segment with the development of controlled drug delivery devices are also described.

Original languageEnglish (US)
Article number22
Pages (from-to)1-9
Number of pages9
JournalJournal of Ophthalmic Inflammation and Infection
Volume4
Issue number1
DOIs
StatePublished - Dec 1 2014

Fingerprint

Endophthalmitis
Pharmacokinetics
Anti-Bacterial Agents
Pharmaceutical Preparations
PubMed
Biological Availability
Half-Life
Language
Safety
Equipment and Supplies
Infection

Keywords

  • Antibiotics
  • Endophthalmitis
  • Intravitreal
  • Pharmacokinetics

ASJC Scopus subject areas

  • Ophthalmology
  • Infectious Diseases

Cite this

Pharmacokinetics of intravitreal antibiotics in endophthalmitis. / Radhika, Medikonda; Mithal, Kopal; Bawdekar, Abhishek; Dave, Vivek; Jindal, Animesh; Relhan, Nidhi; Albini, Thomas A; Pathengay, Avinash; Flynn, Harry W.

In: Journal of Ophthalmic Inflammation and Infection, Vol. 4, No. 1, 22, 01.12.2014, p. 1-9.

Research output: Contribution to journalArticle

Radhika, M, Mithal, K, Bawdekar, A, Dave, V, Jindal, A, Relhan, N, Albini, TA, Pathengay, A & Flynn, HW 2014, 'Pharmacokinetics of intravitreal antibiotics in endophthalmitis', Journal of Ophthalmic Inflammation and Infection, vol. 4, no. 1, 22, pp. 1-9. https://doi.org/10.1186/s12348-014-0022-z
Radhika, Medikonda ; Mithal, Kopal ; Bawdekar, Abhishek ; Dave, Vivek ; Jindal, Animesh ; Relhan, Nidhi ; Albini, Thomas A ; Pathengay, Avinash ; Flynn, Harry W. / Pharmacokinetics of intravitreal antibiotics in endophthalmitis. In: Journal of Ophthalmic Inflammation and Infection. 2014 ; Vol. 4, No. 1. pp. 1-9.
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