Pharmacokinetics of growth hormone secretion in humans induced by growth hormone releasing hormone

Samir K. Gupta, Ranga R. Krishnan, Everett H. Ellinwood, James C. Ritchie, Charles Nemeroff

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This investigation compares the age- and sex-related changes in growth hormone (GH) response to growth hormone releasing hormone (GHRH) in normal subjects using an appropriate pharmacokinetic model. Twenty-five subjects (14 males and 11 females) aged 23-89 yr received a single intravenous bolus dose (1 μg/kg) of GHRH-40 solution. Plasma GH concentration-time profiles are best characterized by a biexponential equation (or one-compartment model) with first-order release and disappearance rates and an equilibration lag time. The harmonic mean release rate half-life is similar for both sexes (males: 12.6 min vs. females: 11.4 min) but significantly different across age groups (23-35 yr: 7.2 min vs. 50-89 yr: 16.8 min). The mean disappearance rate half-life and GHRH-equilibration time lag for females (33.6 and 20.4 min, respectively) and the higher age group subjects (32.4 and 21.6 min, respectively) are significantly longer than those of males (22.8 and 9 min, respectively) and the lower age-group subjects (21.6 and 8.4 min, respectively). The mean metabolic clearance rate of GH is significantly lower (p<0.02) for females than for males (3.1 vs. 4.83 ml/hr·m2). However, the production rate and the amount of GH released by the pituitary for our subjects appear to be very similar for both males (8.7 μg/hr·m2 and 4.65 μg/m2) and females (9.33 μg/hr·m2 and 5.11 μg/m2).

Original languageEnglish
Pages (from-to)1887-1893
Number of pages7
JournalLife Sciences
Volume47
Issue number21
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Growth Hormone-Releasing Hormone
Pharmacokinetics
Human Growth Hormone
Growth Hormone
Age Groups
Half-Life
Metabolic Clearance Rate
Plasmas

ASJC Scopus subject areas

  • Pharmacology

Cite this

Pharmacokinetics of growth hormone secretion in humans induced by growth hormone releasing hormone. / Gupta, Samir K.; Krishnan, Ranga R.; Ellinwood, Everett H.; Ritchie, James C.; Nemeroff, Charles.

In: Life Sciences, Vol. 47, No. 21, 01.01.1990, p. 1887-1893.

Research output: Contribution to journalArticle

Gupta, Samir K. ; Krishnan, Ranga R. ; Ellinwood, Everett H. ; Ritchie, James C. ; Nemeroff, Charles. / Pharmacokinetics of growth hormone secretion in humans induced by growth hormone releasing hormone. In: Life Sciences. 1990 ; Vol. 47, No. 21. pp. 1887-1893.
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