Abstract
The effects of combination hormone therapy of drospirenone (DRSP), a novel progestin with antialdosterone properties, and 17β-estradiol (E2) on hydrochlorothiazide (HCTZ) pharmacokinetics/pharmacodynamics versus placebo were investigated in a double-blind, placebo-controlled, crossover study. Thirty-six postmenopausal women with stage 1 hypertension maintained on 25 mg of HCTZ once daily were randomized to receive either 3 mg of DRSP/ 1 mg of E2 or placebo once daily for 4 weeks. Plasma HCTZ, serum DRSP, E2, potassium, aldosterone, and plasma renin activity were determined at baseline and after 4 weeks. Results showed that the combination of DRSP/E2 plus 25 mg of HCTZ is safe and well tolerated in hypertensive postmenopausal women. The pharmacokinetics of HCTZ were not affected by coadministration of DRSP/E2. The geometric mean ratios and 90% confidence intervals ([HCTZ + DRSP/E2]/[HCTZ + placebo]) for HCTZ (a) area under the serum/plasma concentration-time curve from 0 to 24 hours and (b) maximum plasma concentration were 101 (90.7, 112) and 103 (92.8, 115), respectively. In the HCTZ + DRSP/E2 group, serum potassium, aldosterone, and plasma renin activity all increased in a manner marginally consistent with a beneficial antialdosterone effect, counteracting the HCTZ-induced potassium loss and lowering both systolic and diastolic blood pressure. No dose adjustment is required when DRSP/E2 is added to antihypertensive therapy with HCTZ in hypertensive post-menopausal women.
Original language | English (US) |
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Pages (from-to) | 1292-1302 |
Number of pages | 11 |
Journal | Journal of Clinical Pharmacology |
Volume | 47 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2007 |
Keywords
- Aldosterone
- Aldosterone antagonists
- Diuretics
- Drospirenone
- Drug interactions
- Estradiol
- Hormone therapy
- Hydrochlorothiazide
- Hypertension
- Potassium
- Progesterone
- Progestogens
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)