Abstract
The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a number of the ABC transporter genes, including ABC transporters that contribute to the pharmacokinetics and/or pharmacodynamics of chemotherapy drugs. The role of these transporters and their naturally occurring genetic polymorphisms in cancer and chemotherapy is reviewed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 685-698 |
| Number of pages | 14 |
| Journal | Molecular Cancer Therapeutics |
| Volume | 2 |
| Issue number | 7 |
| State | Published - Jul 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy. / Lockhart, Albert; Tirona, Rommel G.; Kim, Richard B.
In: Molecular Cancer Therapeutics, Vol. 2, No. 7, 01.07.2003, p. 685-698.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy
AU - Lockhart, Albert
AU - Tirona, Rommel G.
AU - Kim, Richard B.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a number of the ABC transporter genes, including ABC transporters that contribute to the pharmacokinetics and/or pharmacodynamics of chemotherapy drugs. The role of these transporters and their naturally occurring genetic polymorphisms in cancer and chemotherapy is reviewed.
AB - The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a number of the ABC transporter genes, including ABC transporters that contribute to the pharmacokinetics and/or pharmacodynamics of chemotherapy drugs. The role of these transporters and their naturally occurring genetic polymorphisms in cancer and chemotherapy is reviewed.
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M3 - Review article
C2 - 12883042
AN - SCOPUS:2142799057
VL - 2
SP - 685
EP - 698
JO - Molecular Cancer Therapeutics
JF - Molecular Cancer Therapeutics
SN - 1535-7163
IS - 7
ER -