Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy

Albert Lockhart, Rommel G. Tirona, Richard B. Kim

Research output: Contribution to journalReview article

98 Citations (Scopus)

Abstract

The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a number of the ABC transporter genes, including ABC transporters that contribute to the pharmacokinetics and/or pharmacodynamics of chemotherapy drugs. The role of these transporters and their naturally occurring genetic polymorphisms in cancer and chemotherapy is reviewed.

Original languageEnglish (US)
Pages (from-to)685-698
Number of pages14
JournalMolecular Cancer Therapeutics
Volume2
Issue number7
StatePublished - Jul 1 2003
Externally publishedYes

Fingerprint

ATP-Binding Cassette Transporters
Pharmacogenetics
Drug Therapy
Neoplasms
Genetic Heterogeneity
Genetic Polymorphisms
Pharmaceutical Preparations
Genes
Pharmacokinetics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy. / Lockhart, Albert; Tirona, Rommel G.; Kim, Richard B.

In: Molecular Cancer Therapeutics, Vol. 2, No. 7, 01.07.2003, p. 685-698.

Research output: Contribution to journalReview article

@article{f7d526aebba94d72be9424ba68d4ba92,
title = "Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy",
abstract = "The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a number of the ABC transporter genes, including ABC transporters that contribute to the pharmacokinetics and/or pharmacodynamics of chemotherapy drugs. The role of these transporters and their naturally occurring genetic polymorphisms in cancer and chemotherapy is reviewed.",
author = "Albert Lockhart and Tirona, {Rommel G.} and Kim, {Richard B.}",
year = "2003",
month = "7",
day = "1",
language = "English (US)",
volume = "2",
pages = "685--698",
journal = "Molecular Cancer Therapeutics",
issn = "1535-7163",
publisher = "American Association for Cancer Research Inc.",
number = "7",

}

TY - JOUR

T1 - Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy

AU - Lockhart, Albert

AU - Tirona, Rommel G.

AU - Kim, Richard B.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a number of the ABC transporter genes, including ABC transporters that contribute to the pharmacokinetics and/or pharmacodynamics of chemotherapy drugs. The role of these transporters and their naturally occurring genetic polymorphisms in cancer and chemotherapy is reviewed.

AB - The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a number of the ABC transporter genes, including ABC transporters that contribute to the pharmacokinetics and/or pharmacodynamics of chemotherapy drugs. The role of these transporters and their naturally occurring genetic polymorphisms in cancer and chemotherapy is reviewed.

UR - http://www.scopus.com/inward/record.url?scp=2142799057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2142799057&partnerID=8YFLogxK

M3 - Review article

C2 - 12883042

AN - SCOPUS:2142799057

VL - 2

SP - 685

EP - 698

JO - Molecular Cancer Therapeutics

JF - Molecular Cancer Therapeutics

SN - 1535-7163

IS - 7

ER -