Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy

A. Craig Lockhart, Rommel G. Tirona, Richard B. Kim

Research output: Contribution to journalReview article

100 Scopus citations

Abstract

The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a number of the ABC transporter genes, including ABC transporters that contribute to the pharmacokinetics and/or pharmacodynamics of chemotherapy drugs. The role of these transporters and their naturally occurring genetic polymorphisms in cancer and chemotherapy is reviewed.

Original languageEnglish (US)
Pages (from-to)685-698
Number of pages14
JournalMolecular cancer therapeutics
Volume2
Issue number7
StatePublished - Jul 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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