TY - JOUR
T1 - Personalized medicine
T2 - Prediction of disease vulnerability in mood disorders
AU - Prendes-Alvarez, Stefania
AU - Nemeroff, Charles
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Personalized or precision medicine is a medical discipline that proposes tailoring health care to each individual by integrating data from their genetic makeup, epigenetic modifications, other biomarkers, clinical symptoms and environmental exposures. Currently, patients typically present for treatment of mood disorders relatively late in the disease course and this is of great concern both because delay in attaining remission reduces the success of subsequent treatment and depressive episodes have negative cumulative effects on the brain and body. In this article we will discuss progress in personalized medicine for predicting disease vulnerability for major depressive disorder and bipolar disorder. We will review non-biological risk factors, genetic factors, epigenetic factors, as well as the roll of neuroimaging and electroencephalograms. Putting together this information with poise psychiatrists to make biological, system-based evaluations for their patients.
AB - Personalized or precision medicine is a medical discipline that proposes tailoring health care to each individual by integrating data from their genetic makeup, epigenetic modifications, other biomarkers, clinical symptoms and environmental exposures. Currently, patients typically present for treatment of mood disorders relatively late in the disease course and this is of great concern both because delay in attaining remission reduces the success of subsequent treatment and depressive episodes have negative cumulative effects on the brain and body. In this article we will discuss progress in personalized medicine for predicting disease vulnerability for major depressive disorder and bipolar disorder. We will review non-biological risk factors, genetic factors, epigenetic factors, as well as the roll of neuroimaging and electroencephalograms. Putting together this information with poise psychiatrists to make biological, system-based evaluations for their patients.
KW - Disease vulnerability
KW - Mood disorders
KW - Personalized medicine
KW - Prediction
UR - http://www.scopus.com/inward/record.url?scp=85006137629&partnerID=8YFLogxK
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U2 - 10.1016/j.neulet.2016.09.049
DO - 10.1016/j.neulet.2016.09.049
M3 - Article
C2 - 27746310
AN - SCOPUS:85006137629
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
ER -