TY - JOUR
T1 - Personalized medicine in psychiatry
T2 - Problems and promises
AU - Ozomaro, Uzoezi
AU - Wahlestedt, Claes
AU - Nemeroff, Charles B.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/5/16
Y1 - 2013/5/16
N2 - The central theme of personalized medicine is the premise that an individual's unique physiologic characteristics play a significant role in both disease vulnerability and in response to specific therapies. The major goals of personalized medicine are therefore to predict an individual's susceptibility to developing an illness, achieve accurate diagnosis, and optimize the most efficient and favorable response to treatment. The goal of achieving personalized medicine in psychiatry is a laudable one, because its attainment should be associated with a marked reduction in morbidity and mortality. In this review, we summarize an illustrative selection of studies that are laying the foundation towards personalizing medicine in major depressive disorder, bipolar disorder, and schizophrenia. In addition, we present emerging applications that are likely to advance personalized medicine in psychiatry, with an emphasis on novel biomarkers and neuroimaging.
AB - The central theme of personalized medicine is the premise that an individual's unique physiologic characteristics play a significant role in both disease vulnerability and in response to specific therapies. The major goals of personalized medicine are therefore to predict an individual's susceptibility to developing an illness, achieve accurate diagnosis, and optimize the most efficient and favorable response to treatment. The goal of achieving personalized medicine in psychiatry is a laudable one, because its attainment should be associated with a marked reduction in morbidity and mortality. In this review, we summarize an illustrative selection of studies that are laying the foundation towards personalizing medicine in major depressive disorder, bipolar disorder, and schizophrenia. In addition, we present emerging applications that are likely to advance personalized medicine in psychiatry, with an emphasis on novel biomarkers and neuroimaging.
KW - Endophenotypes
KW - Environmental factors
KW - Epigenetics
KW - Major depressive disorder
KW - Neuroimaging genetics
KW - Personalized medicine
KW - Pharmacogenomics
KW - Psychiatric hereditability
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=84878461822&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878461822&partnerID=8YFLogxK
U2 - 10.1186/1741-7015-11-132
DO - 10.1186/1741-7015-11-132
M3 - Review article
C2 - 23680237
AN - SCOPUS:84878461822
VL - 11
JO - BMC Medicine
JF - BMC Medicine
SN - 1741-7015
IS - 1
M1 - 132
ER -