Personalized medicine in psychiatry: Problems and promises

Research output: Contribution to journalReview articlepeer-review

140 Scopus citations


The central theme of personalized medicine is the premise that an individual's unique physiologic characteristics play a significant role in both disease vulnerability and in response to specific therapies. The major goals of personalized medicine are therefore to predict an individual's susceptibility to developing an illness, achieve accurate diagnosis, and optimize the most efficient and favorable response to treatment. The goal of achieving personalized medicine in psychiatry is a laudable one, because its attainment should be associated with a marked reduction in morbidity and mortality. In this review, we summarize an illustrative selection of studies that are laying the foundation towards personalizing medicine in major depressive disorder, bipolar disorder, and schizophrenia. In addition, we present emerging applications that are likely to advance personalized medicine in psychiatry, with an emphasis on novel biomarkers and neuroimaging.

Original languageEnglish (US)
Article number132
JournalBMC Medicine
Issue number1
StatePublished - May 16 2013


  • Endophenotypes
  • Environmental factors
  • Epigenetics
  • Major depressive disorder
  • Neuroimaging genetics
  • Personalized medicine
  • Pharmacogenomics
  • Psychiatric hereditability
  • Schizophrenia

ASJC Scopus subject areas

  • Medicine(all)


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